| 邢时妹,曹永红,戴武.绝经后女性2 型糖尿病病人骨钙素水平与糖尿病肾脏病的相关性研究[J].安徽医药,2022,26(9):1818-1821. |
| 绝经后女性2 型糖尿病病人骨钙素水平与糖尿病肾脏病的相关性研究 |
| Correlation between serum osteocalcin level and diabetic kidney disease in postmenopausal women with type 2 diabetes mellitus |
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| DOI：10.3969/j.issn.1009-6469.2022.09.028 |
| 中文关键词: 糖尿病肾病 绝经后期 2型糖尿病 骨钙素 |
| 英文关键词: Diabetic nephropathies Postmenopause Type 2 diabetes mellitus Osteocalcin |
| 基金项目:合肥市卫生健康应用医学研究项目(合卫科教〔2019〕172号)；安徽医科大学校科研基金项目(2020xkj247) |
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| 中文摘要: |
| 目的探讨绝经后女性2型糖尿病(T2DM)病人骨钙素水平与糖尿病肾脏病(DKD)之间的相关性。方法选取2018年5 月至2019 年6 月在合肥市第二人民医院广德路院区住院的绝经后女性T2DM 病人203 例，根据尿白蛋白与肌酐比值(UACR)水平分为正常白蛋白尿组(N-DKD组，138例，UACR<30 mg/g)，DKD组(65例，UACR≥30 mg/g)。检测并比较两组病人临床、生化指标及骨钙素水平的差异，同时进行多因素logistic回归分析探索DKD与骨钙素的相关性。结果两组间病程、体质量指数(BMI)、尿酸、骨钙素及25羟维生素D3［25(OH)D3］比较差异有统计学意义(P<0.05)，其中DKD组病程11(6，16)年、BMI(25.51±3.72)kg/m2、尿酸331(270，400)μmol/L明显高于N-DKD组［9(3，12)年、(24.40±3.55)kg/m2和284(243，329)μmol/L］(P<0.05)，而DKD 组骨钙素(12.28±4.88)μg/L、25(OH)D3(13.89±3.60)μg/L 明显低于N-DKD 组［(14.23±4.68)μg/L、(16.56±6.61)μg/L］(P<0.05)，其他临床、生化和骨代谢指标差异无统计学意义(P>0.05)；DKD组骨钙素下降者所占比例66.2%(43/65)明显大于N-DKD 组50.7%(70/138)(P<0.05)；骨钙素水平下降组UACR 12.30(5.85，62.08)mg/g明显高于骨钙素正常组7.95(3.15，29.75)mg/g(P<0.05)；多因素logistic 回归分析显示:骨钙素、25(OH)D3 是2 型DKD 的保护性因素［OR=0.91，95%CI:(0.85，0.97)；OR=0.92，95%CI:(0.85，0.98)］。结论骨钙素是绝经后女性2型DKD保护性因素。 |
| 英文摘要: |
| Objective To investigate the relationship between serum osteocalcin (OC) level and diabetic kidney disease (DKD) in postmenopausal women with type 2 diabetes mellitus(T2DM).Methods Two hundred and three postmenopausal women with T2DM in Hefei Second People's Hospital from May 2018 to June 2019 were selected and assigned into two groups: T2DM patients with normal albuminuria Group (N-DKD Group, n = 138, UACR<30 mg/g) and DKD patients Group (DKD Group, n = 65, UACR≥30 mg/g) according to urine albuminuria-to-creatinine ratio (UACR) level. The differences in clinical data, biochemical indicators and OC levels between the two groups were detected and compared, and the correlation between DKD and OC was analyzed by multivariate Logistic regression.Results There were significant differences in the course of disease, body mass index (BMI), uric acid (UA), OC and 25-hydroxy vitamin D3 [25(OH)D3] between the two groups (P<0.05), of which the course of the DKD group was 11 (6, 16) years, BMI (25.51±3.72) kg/m2 and UA 331 (270, 400) μmol/L were significantly higher than those in N-DKD Group [9 (3,12) years, (24.40±3.55) kg/m2 and 284 (243, 329) μmol/L] (P < 0.05), OC (12.28±4.88) ng/ ml and 25(OH)D3 (13.89±3.60) μg/L in DKD Group were significantly lower than those in N-DKD Group [(14.23±4.68) μg/L and (16.56±6.61) μg/L] (P < 0.05), there were no significant differences in other clinical, biochemical and bone metabolism indexes (P>0.05). The proportion of OC decreased 66.2% (43/65) in DKD Group was higher than that in N-DKD Group 50.7% (70/138), and the difference was statistically significant (P<0.05). UACR of OC decreased group[12.30 (5.85, 62.08) mg/g] was higher than that of OC normal group [7.95 (3.15, 29.75) mg/g], and the difference was statistically significant(P<0.05). The results of multivariate logistic regression analysis indicated that OC and 25(OH)D3 were protective factors for DKD[OR=0.91, 95%CI:(0.85, 0.97); OR=0.92, 95%CI:(0.85, 0.98)].Conclusion OC is a protective factor for postmenopausal women with type 2 diabetic kidney disease. |
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