| 罗国英,韦励,罗小敏,等.血清维生素 A、视黄醇结合蛋白 4表达与子宫内膜异位症的相关性研究[J].安徽医药,2022,26(10):1973-1976. |
| 血清维生素 A、视黄醇结合蛋白 4表达与子宫内膜异位症的相关性研究 |
| Study on correlation between serum vitamin A, retinol binding protein 4 expressions and endometriosis |
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| DOI：10.3969/j.issn.1009-6469.2022.10.015 |
| 中文关键词: 子宫内膜异位症 视黄醇结合蛋白 4 维生素 A |
| 英文关键词: endometriosis retinol binding protein 4 vitamin A |
| 基金项目:东莞市社会科技发展(一般)项目( 201850715001785) |
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| 中文摘要: |
| 目的研究子宫内膜异位症病人血清维生素 A、视黄醇结合蛋白 4(RBP4)表达水平。方法选取 2018年 6月至 2020年 1月在东莞市人民医院行腹腔镜手术治疗的子宫内膜异位症病人 68例(子宫内膜异位症组)为研究对象，均经术后病理检查确诊；同期选择在本院体检健康的女性 70例为对照组。采用酶联免疫吸附( ELISA)法检测血清中维生素 A、RBP4水平，用化学发光免疫分析法检测病人黄体生成素(LH)、雌二醇( E2)、卵泡刺激素( FSH)、孕酮( P)、催乳素( PRL)水平。采用受试者工作曲线( ROC)分析维生素 A、RBP4及二者联合对子宫内膜异位症预测价值。 Pearson法分析维生素 A、RBP4与性激素水平的相关性。结果子宫内膜异位症组血清维生素 A的水平为( 0.35±0.09)μg/L，低于对照组( 0.57±0.11)μg/L(P<0.05)，血清 RBP4 |
| 英文摘要: |
| Objective To study the expression levels of serum vitamin A and retinol binding protein 4 (RBP4) in patients with endo. metriosis.Methods A total of 68 patients with endometriosis (endometriosis group) who underwent laparoscopic surgery in DongguanPeople's Hospital from June 2018 to January 2020 were selected as the research objects, and were confirmed by postoperative patholog.ical examination; at the same time, 70 healthy women in our hospital were selected as the control group. The levels of serum vitamin Aand RBP4 were detected by enzyme-linked immunosorbent assay (ELISA), the levels of luteinizing hormone (LH), estradiol (E2), folliclestimulating hormone (FSH), progesterone (P) and prolactin (PRL) were detected by chemiluminescence immunoassay. Receiver operat.ing curve (ROC) was used to analyze the predictive value of vitamin A, RBP4 and their combination on endometriosis. Furthermore,Pearson method was used to analyze the correlation between vitamin A, RBP4 and sex hormone levels.Results The levels of serum vi. tamin A in the endometriosis group were (0.35±0.09) μg/L, lower than those in the control group (0.57±0.11) μg/L (P<0.05), and levels of serum RBP4 (30.61±6.58) ng/L, FSH (4.35±1.62) mIU/mL, LH (4.82±1.86) mIU/mL, PRL (0.02±0.01) mg/L, E2 (515.86±134.25)pmol/L and P (2.15±0.70) nmol/L were higher than those in the control group (14.06±4.21) ng/L, (3.28±1.09) mIU/mL, (3.30±1.15)mIU/mL,(0.01±0.00)mg/L, (291.84±97.37) pmol/L, (1.39±0.47)nmol/L, respectively (P<0.05); the level of serum vitamin A in pa. tients with stage Ⅲ-Ⅳ endometriosis was lower than that in patients with stage Ⅰ-Ⅱ(P<0.05), and the levels of serum RBP4, FSH, LH, PRL, E2 and P were higher than those in patients with stage Ⅰ-Ⅱ, respectively (P<0.05); the sensitivity and specificity of vitaminA, RBP4 and their combination for endometriosis diagnosis were good, and the value of their combination in the diagnosis of endometri.osis was higher; Pearson analysis showed that vitamin A was negatively correlated with FSH, LH, PRL, E2 and P (P<0.05); RBP4 was positively correlated with FSH, LH, PRL, E2 and P (P<0.05).Conclusions The expression of vitamin A in serum of patients with endo. metriosis is down-regulated, and the expression of RBP4 is up-regulated, and have certain diagnostic value for endometriosis. |
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