| 顾新红,王亚民,蔡海建,等.早期肠内营养和益生菌对急性胰腺炎肠黏膜屏障功能和免疫功能的影响[J].安徽医药,2022,26(10):1977-1980. |
| 早期肠内营养和益生菌对急性胰腺炎肠黏膜屏障功能和免疫功能的影响 |
| Effect of early enteral nutrition and probiotics on maintenance of the intestinal mucosal barrier function and immunological function in acute pancreatitis patients |
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| DOI：10.3969/j.issn.1009-6469.2022.10.016 |
| 中文关键词: 胰腺炎 肠道营养 肠黏膜屏障 益生菌 免疫球蛋白类 |
| 英文关键词: Pancreatitis Enteral nutrition Intestinal mucosal barrier Probiotics Immunoglobulins |
| 基金项目: |
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| 中文摘要: |
| 目的评价早期肠内营养、补充益生菌对急性胰腺炎( AP)病人肠黏膜屏障功能和免疫功能指标的疗效。方法选取 2015年 1月至 2020年 12月南通市第一人民医院及南通市第二人民医院收治的 AP病人 160例，按照给予肠内营养的不同时间点，按照随机数字表法随机分为早期肠内营养组(观察组 1，n=85)，常规营养组(观察组 2，n=75)。观察组 1予入院后 48 h内给予益生菌、肠内营养；观察组 2先给予肠外营养 1周，再给予肠内营养；另选择健康体检人员 72例为对照组。于病人入院第 1、 7、14天分别检测并比较 3组间血清内毒素、 D-乳酸水平、尿乳果糖 /甘露醇排泄率、免疫球蛋白 IgG、免疫球蛋白 IgM的浓度。结 |
| 英文摘要: |
| Objective To evaluate the curative effect of early enteral nutrition (EEN) and probiotics on maintenance of the intestinalmucosal barrier and immunological function in acute pancreatitis (AP) patients.Methods A total of 160 AP cases admitted to The Sec. ond People's Hospital of Nantong City and The First People's Hospital of Nantong City from Januarry 2015 to December 2020 were en.rolled into this study. According to different time points of enteral nutrition, the patients were assigned into early enteral nutrition group(observation group 1, n=85) and routine nutrition group (observation group 2, n=75) by random number method. Early enteral nutritionand probiotics were started within 48h after admission in observation group 1. Parenteral nutrition was given to patients in observationgroup 2 for one week, and then enteral nutrition was administered. Another 72 healthy people were enrolled as the control group. Theserum endotoxin, D-lactate, urine lactulose/mannitol excretion rate, immunoglobulin G and immunoglobulin M were determined and compared on the 1st, 7th and 14th day after admission.Results On the 1st day of admission, there were no significant differences in se. rum endotoxin, D-lactate and urine lactulose/mannitol excretion rate between the two observation groups, but these indicators were sig.nificantly higher than those in the control group (P<0.05) [endotoxin: (0.69±0.08) vs. (2.06±0.39) vs. (2.08±0.38)μg/L,D-lactate: (3.06± 0.90) vs. (13.48±0.75) vs. (13.39±1.23)μg/L, lactulose/mannitol excretion rate: (0.16±0.10) vs. (0.51±0.21) vs. (0.50±0.17)], while the concentrations of immunoglobulin G and immunoglobulin M were significantly lower [IgG: (18.84±2.12) vs. (14.32±2.45) vs. (14.27± 2.39) g/L,IgM: (1.83±0.36) vs. (1.59±0.42) vs. (1.48±0.33) g/L]. On the 7th day of admission, there were significant differences in serum |
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