食管癌组织白细胞介素 -6/信号转导子与转激活子 3通路相关蛋白的表达及其与临床分期、分化程度的关系研究

谢宇; 邓倩曦

文章摘要

谢宇,邓倩曦.食管癌组织白细胞介素 -6/信号转导子与转激活子 3通路相关蛋白的表达及其与临床分期、分化程度的关系研究[J].安徽医药,2022,26(10):2013-2017.

食管癌组织白细胞介素 -6/信号转导子与转激活子 3通路相关蛋白的表达及其与临床分期、分化程度的关系研究

Expressions of interleukin-6/signal transducer and activator 3 pathway related proteins in esophageal carcinoma and their relationships with clinical stage and differentiation degrees

DOI：10.3969/j.issn.1009-6469.2022.10.025

中文关键词: 食管肿瘤细胞周期蛋白 D1 白细胞介素 -6 信号转导子与转激活子 3 临床分期分化程度

英文关键词: Esophageal neoplasms Cyclin D1 Interleukin-6 Signal transducer and activator 3 Clinical stage Differentia. tion degrees

基金项目:

作者	单位
谢宇	绵阳市第三人民医院四川省精神卫生中心消化内科，四川绵阳 621000
邓倩曦	绵阳市第三人民医院四川省精神卫生中心消化内科，四川绵阳 621000

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中文摘要:

目的检测食管癌组织白细胞介素 -6(IL-6)/信号转导子与转激活子 3(STAT3)通路相关蛋白表达，并分析其与临床分期、分化程度的关系。方法选取绵阳市第三人民医院(四川省精神卫生中心) 2018年 10月至 2020年 7月 109例食管癌病人，均实施切除手术或活检，保存有癌组织和癌旁正常组织。采用免疫组化法检测 IL-6、STAT3、B淋巴细胞瘤 -相关死亡启动子(Bcl-xl)、细胞周期蛋白 D1(CyclinD1)蛋白表达。对比癌组织和癌旁正常组织上述蛋白表达；对比不同临床病理特征病人上述蛋白表达；采用 Spearman相关性分析探讨上述蛋白表达与临床分期、分化程度的关系。结果癌组织 IL-6、STAT3、磷酸化信号转导子与转激活子 3(p-STAT3)、 Bcl-xl、CyclinD1蛋白阳性表达率分别为 89.91%、78.90%、84.40%、76.15%、71.56%，均高于癌旁正常组织的 11.01%、25.69%、28.44%、44.95%、42.20%(P<0.05)； Ⅲ~Ⅳ期、肿瘤长径 ≥5 cm、有淋巴结转移、未/低分化病人癌组织 IL-6、STAT3、p-STAT3、Bcl-xl、CyclinD1蛋白阳性表达率均分别高于 Ⅰ~Ⅱ期、肿瘤长径 <5 cm、无淋巴结转移、中/高分化病人( P<0.05)；癌组织 IL-6、STAT3、p-STAT3、Bcl-xl、CyclinD1蛋白表达与临床分期均呈正相关( r=0.81、0.83、0.79、0.72、0.71，P=

英文摘要:

Objective To detect the expressions of interleukin-6 (IL-6) / signal transducer and activator 3 (STAT3) pathway relatedproteins in esophageal carcinoma, and to analyze their relationships with clinical stage and differentiation degrees.Methods A total of 109 patients with esophageal cancer admitted to the Third Hospital of Mianyang (Sichuan Mental Health Center) from October 2018 toJuly 2020 were selected. All patients underwent resection or biopsy, and cancer tissues and adjacent normal tissues were preserved.The expressions of IL-6, STAT3, B-cell lymphoma related death promoter (Bcl-xl) and Cyclin D1 (CyclinD1) were detected by immuno.histochemistry, which were compared between the cancer tissues and the adjacent normal tissues. The expressions of the above proteinsin patients with different clinicopathological features were compared. Spearman correlation analysis was used to investigate the relation.ships between the expressions of these proteins and clinical stages, differentiation degrees.Results The positive expression rates of IL-6, STAT3, phosphorylation signal transducer and activator 3 (p-STAT3), Bcl-xl and CyclinD1 in cancer tissues were 89.91%, 78.90%,84.40%, 76.15%, 71.56%, which were higher than those of 11.01%, 25.69%, 28.44%, 44.95%, 42.20% in adjacent normal tissues (P < 0.05). The positive expression rates of IL-6, STAT3, p-STAT3, Bcl-xl and CyclinD1 proteins in stage Ⅲ-Ⅳ, maximum tumor diameter≥5cm, lymph node metastasis, undifferentiated / poorly differentiated patients were higher than those in stage Ⅰ-Ⅱ, maximum tumor di. ameter < 5cm, no lymph node metastasis, and moderately / highly differentiated patients (P < 0.05). The expressions of IL-6, STAT3, p-STAT3, Bcl-xl and CyclinD1 were positively correlated with clinical stage (r = 0.81, 0.83, 0.79, 0.72, 0.71, P=0.010, 0.007, 0.005, 0.018, 0.023), and negatively correlated with differentiation degrees (r =.0.81,.0.79,.0.71,.0.70,P = 0.011, 0.019, 0.023, 0.038, 0.040).Conclusion The positive expression rates of IL-6, STAT3, p-STAT3, Bcl-xl, CyclinD1 proteins in esophageal carcinoma tis.sues are high, and they are positively correlated with clinical stage, and negatively correlated with differentiation degrees

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