文章摘要
马志君,吉洁,呼铁民,等.血清 8-羟基脱氧鸟苷、星形胶质源性蛋白 B表达与颅内动脉瘤夹闭术后血管痉挛的相关性分析[J].安徽医药,2022,26(10):2021-2025.
血清 8-羟基脱氧鸟苷、星形胶质源性蛋白 B表达与颅内动脉瘤夹闭术后血管痉挛的相关性分析
Correlation analysis of serum 8-hydroxy-2 deoxyguanosine and S100 protein B expressions and vasospasm after intracranial aneurysm clipping
  
DOI:10.3969/j.issn.1009-6469.2022.10.027
中文关键词: 颅内动脉瘤  血管痉挛,颅内  8-羟基脱氧鸟苷  星形胶质源性蛋白 B
英文关键词: Intracranial aneurysm  Vasospasm,intracranial  8-hydroxy-2 deoxyguanosine  S100 protein B
基金项目:
作者单位E-mail
马志君 承德医学院附属医院神经外科河北承德 067000  
吉洁 承德医学院附属医院病案室河北承德 067000  
呼铁民 承德医学院附属医院神经外科河北承德 067000 ms079h@163.com 
王维兴 承德医学院附属医院神经外科河北承德 067000  
张继伟 承德医学院附属医院神经外科河北承德 067000  
田甜 承德医学院附属医院神经外科河北承德 067000  
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中文摘要:
      目的分析颅内动脉瘤夹闭术后病人血清 8-羟基脱氧鸟苷( 8OHdG)、星形胶质源性蛋白 B(S100B)表达情况,并分析二者与术后血管痉挛( CVS)的关系。方法回顾性分析 2017年 5月至 2019年 5月承德医学院附属医院收治的颅内动脉瘤病人 190例为研究对象,根据 CVS评定方法将病人分为无 CVS组、轻度 CVS组、中度 CVS组、重度 CVS组。收集比较病人一般资料,采用酶联免疫吸附法( ELISA)法测定并比较受试者血清 8OHdG、S100B水平,采用二元 logistic回归分析影响颅内动脉瘤病人夹闭术后 CVS的危险因素,绘制受试者工作特征曲线( ROC)曲线评价血清 8OHdG、S100B水平对颅内动脉瘤病人夹闭术后 CVS的诊断价值。结果术后不同程度 CVS计 147例。 CVS组病人血清 8OHdG、S100B水平均明显低于术前( P<0.05)无 CVS组、轻度 CVS组、中度 CVS组、重度 CVS组颅内动脉瘤夹闭术病人术后血清 8OHdG、S100B水平均依次升高[(223.78±33.6,6)ng/ L比( 328.37±67.75)ng/L比( 436.53±119.21)ng/L比( 499.39±152.67)ng/L、(0.76±0.21)μg/L比( 1.01±0.39)μg/L比( 1.30±0.45)μg/ L比( 1.55±0.52)μg/L,P<0.05]。不同程度 CVS组病人 Hunt-Hess分级 Ⅲ~Ⅳ级病人比例差异有统计学意义( P<0.05)。二元 lo. gistic回归分析显示, Hunt-Hess分级 Ⅲ~Ⅳ级、血清 8OHdG、S100B水平高表达是颅内动脉瘤夹闭术后病人发生 CVS的危险因素(P<0.05)。血清 8OHdG、S100B水平诊断颅内动脉瘤夹闭术后病人发生 CVS的 ROC曲线下面积 AUC分别为 0.87、0.86,二者联合检测诊断 AUC为 0.95。结论血清 8OHdG、S100B水平异常高表达可能与颅内动脉瘤夹闭术后 CVS发生发展有关,且二者联合检测对是否发生 CVS有较高诊断价值,可为临床寻求可靠生物学指标早期诊断颅内动脉瘤夹闭术后病人是否发生 CVS提供一定参考。
英文摘要:
      Objective To analyze the expressions of serum 8-hydroxy-2 deoxyguanosine (8OHdG) and serum S100 protein B(S100B) in patients undergoing intracranial aneurysm clipping, and to analyze the relationship between them and postoperative cerebralvasospasm (CVS).Methods A total of 190 patients with intracranial aneurysms, admitted to The Affiliated Hospital of Chengde Medi.cal College from May 2017 to May 2019, were retrospectively analyzed. According to the CVS evaluation method, the patients were as.signed into non-CVS group, mild CVS group, moderate CVS group and severe CVS group. The general data of patients were collectedand compared, the levels of serum 8OHdG and S100B were measured and compared by enzyme-linked immunosorbent assay (ELISA),the risk factors for CVS after clipping were analyzed by binary Logistic regression, and the receiver operating characteristic (ROC)curve was drawn to evaluate the diagnostic value of serum 8OHdG and S100B levels for CVS after intracranial aneurysm clipping. Re. sults 147 cases had CVs of different degrees after operation.The levels of serum 8OHdG and S100B in different degrees of CVSgroups were significantly lower than those before operation (P < 0.05), while the levels of serum 8OHdG and S100B in patients with in.tracranial aneurysm clipping were increased successively in non-CVS group, mild CVS group, moderate CVS group and severe CVS group [(223.78±33.66) ng/L vs. (328.37±67.75) ng/L vs. (436.53±119.21) ng/L vs. (499.39±152.67) ng/L, (0.76±0.21) μg/L vs. (1.01± 0.39) ) μg/L vs. (1.30±0.45) μg/L vs. (1.55±0.52) μg/L; P < 0.05]. There was significant difference in the proportion of patients with Hunt-Hess grade Ⅲ -Ⅳ among groups with different degrees of CVS (P < 0.05). Binary Logistic regression analysis results showed that Hunt-Hess grade Ⅲ -Ⅳ, high expressions of serum 8OHdG and S100B were the risk factors for CVS after intracranial aneurysm clip. ping (P < 0.05). The areas under ROC curve (AUC) of serum 8OHdG and S100B levels in the diagnosis of CVS after intracranial aneu. rysm clipping were 0.87 and 0.86, respectively, and the AUC of combined detection was 0.95.Conclusion The abnormally high ex.pressions of serum 8OHdG and S100B may be related to the occurrence and development of CVS after intracranial aneurysm clipping.The joint detection of the two has high diagnostic value for the occurrence of CVS, which can provide certain reference for clinicallyseeking reliable biological indicators for the early diagnosis of CVS after intracranial aneurysm clipping.
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