| 张程程,费素娟.血清胱抑素 C、癌胚抗原、抗原 199联合检测在结直肠癌诊断中的价值研究[J].安徽医药,2022,26(10):2038-2041. |
| 血清胱抑素 C、癌胚抗原、抗原 199联合检测在结直肠癌诊断中的价值研究 |
| The value of serum cystatin C, carcinoembryonic antigen, antigen 199 in the diagnosis of colorectal cancer |
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| DOI：10.3969/j.issn.1009-6469.2022.10.030 |
| 中文关键词: 结直肠肿瘤 胱抑素 C 癌胚抗原 抗原 199 早期诊断 |
| 英文关键词: Colorectal neoplasms Serum cystatin C Carcino-embryonic antigen Antigen 199 Early diagnosis |
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| 中文摘要: |
| 目的探讨术前血清胱抑素 C(Cys C)癌胚抗原( CEA)及抗原 199(CA199)在结直肠癌中的表达特点及诊断价值。方选取 2018年 1月至 2020年 1月徐州医科大学、附属医院经手术后病理学证实的结直肠癌病人 215例(结直肠癌组)、结直肠良法性疾病病人 110例(对照组)检测两组血清 Cys C、CEA、CA199水平，将结直肠癌病人根据 TNM分期、是否发生淋巴结转移进行亚组分析；采用 logistic回归分，析结直肠癌的危险因素；并用受试者工作特征( ROC)曲线评价 Cys C、CEA、CA199及 3种指标联合检测诊断结直肠癌的效能。结果结直肠癌组病人的血清 Cys C［0.85(0.77，1.16)mg/L］、 CEA［2.59(1.67，5.06)μg/L］、 CA199［11.58(8.20，37.90)U/mL］水平显著高于对照组［ 0.73(0.68，0.92)mg/L、1.76(1.11，2.44)μg/L、9.03(5.90，13.21)U/mL，均 P <0.05］； TNM分期 Ⅲ期+Ⅳ期、发生淋巴结转移的结直肠癌病人的血清 Cys C、CEA、CA199水平均显著高于 TNM分期 Ⅰ期+Ⅱ期、未发生淋巴结转移的结直肠癌病人( P<0.05)；年龄、 Cys C、CEA、CA 199均为结直肠癌发生的危险因素；结直肠癌诊断的 ROC曲线下面积，三种指标联合检测以及 Cys C、CEA、CA199单独检测的结果分别为 0.738、0.702、0.690、0.662，3种指标联合检测对结直肠癌的诊断效能较好。结论 Cys C、CEA、CA199在结直肠癌病人血清中显著升高，三者联合应用对于结直肠癌的术前诊断有重要价值。 |
| 英文摘要: |
| Objective To explore the expressive feature and diagnostic value of serum cystatin C (Cys C),carcinoembryonic antigen(CEA)and antigen 199 (CA199)in patients with colorectal cancer.Methods A total of 215 patients with colorectal cancer (colorectalcancer group) and 110 benign colorectal diseases subjects (control group), who were pathologically confirmed after undergoing surgeryin The Affiliated Hospital of Xuzhou Medical University from January 2018 to January 2020, were enrolled in this study. Serum levelsof Cys C, CEA and CA199 were measured in both groups. Patients with colorectal cancer were subdivided according to TNM stagingand lymph node metastasis condition. Logistic regression analysis was made of the risk factors for colorectal cancer. The receiver operat.ing characteristic (ROC) curve was also used to evaluate the efficacy of Cys C, CEA, CA199 and these three combined indicators in thediagnosis of colorectal cancer.Results Levels of serum Cys C [0.85(0.77,1.16) mg/L],CEA[2.59 (1.67,5.06) μg/L]and CA199[11.58(8.20,37.90) U/mL]in patients with colorectal cancer were significantly higher than those in the control group [0.73 (0.68,0.92) mg/L,1.76 (1.11,2.44)μg/L,9.03(5.90,13.21) U/mL; all P<0.05]. The levels of the above indicators in colorectal cancer patients with lymphat.ic metastasis in Ⅲ and Ⅳ stages were significantly higher than those in I,Ⅱ phase of TNM staging,and those without lymph node metas.tasis (P<0.05). Age, Cys C, CEA, CA199 were all risk factors for colorectal cancer. The area under the ROC curve for the diagnosis ofcolorectal cancer, the combined detection of the three indicators and the separate detection of Cys C, CEA, and CA199 were 0.738,0.702, 0.690, and 0.662, respectively. The combined detection of the three indicators had a better diagnostic effect on colorectal cancer.Conclusions Cys C, CEA, and CA199 are significantly increased in the serum of patients with colorectal cancer. The combined appli.cation of the three is of great value in the pre-operative diagnosis of colorectal cancer. |
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