| 张世杰,宋晓杰,王利军,等.免疫球蛋白 A肾病病人血清白细胞介素 -17、白细胞介素 -18表达变化与乙型肝炎病毒感染的相关性[J].安徽医药,2022,26(10):2086-2089. |
| 免疫球蛋白 A肾病病人血清白细胞介素 -17、白细胞介素 -18表达变化与乙型肝炎病毒感染的相关性 |
| Correlation between serum IL-17 and IL-18 expressions and hepatitis B virus infection in patients with IgA nephropathy |
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| DOI：10.3969/j.issn.1009-6469.2022.10.041 |
| 中文关键词: 肾小球肾炎， IGA 白细胞介素 -17 白细胞介素 -18 乙型肝炎病毒 |
| 英文关键词: Glomerulonephritis,IGA Interleukin-17 Interleukin-18 Hepatitis B virus |
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| 中文摘要: |
| 目的探讨免疫球蛋白 A(IgA)肾病病人血清白细胞介素 -17(IL-17)、白细胞介素 -18(IL-18)表达变化与乙型肝炎病毒(HBV)感染的相关性。方法选取 2016年 3月至 2019年 3月南阳市中心医院 224例 IgA肾病病人，其中乙型肝炎病毒感染 67例作为感染组，未感染病人 157例作为未感染组。另选取无肾脏疾病的单纯乙型肝炎病毒感染病人 67例作为对照组。对比三组不同乙肝病毒脱氧核糖核酸( HBV-DNA)载量病人、乙肝表面抗原( HBeAg)阴性及阳性病人血清 IL-17、IL-18水平，分析血清 IL-17、IL-18对 IgA肾病病人 HBV感染的诊断价值及与 HBV-DNA载量、肝功能［谷草转氨酶( AST)、谷丙转氨酶( ALT)］相关性。结果三组血清 IL-17、IL-18水平对比差异有统计学意义( P<0.05)，且未感染组 IL-17(12.68±2.13)ng/L、IL-18(360.37± |
| 英文摘要: |
| Objective To investigate the correlation between the changes in serum interleukin-17 (IL-17) and interleukin-18 (IL-18) expressions and hepatitis B virus (HBV) infection in patients with IgA nephropathy.Methods A total of 224 patients with IgA ne.phropathy, admitted to The Second People's Hospital of Pingdingshan City and Nanyang Central Hospital from March 2016 to March2019, were enrolled in the study. Among them, 67 patients infected with hepatitis B virus were chosen as the infection group, and 157patients uninfected were taken as the uninfected group. Another 67 patients with simple hepatitis B virus infection were selected as thecontrol group. A comparison was made of the serum IL-17 and IL-18 levels among the three groups, including patients with different HBV-DNA loads and HBeAg negative and positive patients. The diagnostic value of serum IL-17 and IL-18 for HBV infection in pa. tients with IgA nephropathy and its correlation with HBV-DNA load and liver function [aspartate aminotransferase (AST), alanine ami. notransferase (ALT)].Results The serum levels of IL-17 and IL-18 in the three groups were significantly different (P<0.05), and the levels of IL-17 and IL-18 in the uninfected group were lower than those in the control group[(12.68±2.13)ng/L vs.(14.78±2.69)ng/L, (360.37±25.37)ng/L vs.(412.37±30.25)ng/L](P<0.05). The combined AUC value of serum IL-17 and IL-18 for the diagnosis of HBV in. fection in patients with IgA nephropathy was higher than that of serum IL-17 and IL-18 alone. The sensitivity was 79.10%, and the specificity was 94.90%, Serum IL-17 and IL-18 levels in HBV-DNA high-load patients were higher than those in low-load patients [(19.21±3.12)ng/L vs.(15.41±2.94)ng/L, (547.34±40.12)ng/L vs. (431.57±35.69)ng/L](P<0.05). Serum IL-17 and IL-18 levels were posi. tively correlated with HBV-DNA load in patients with IgA nephropathy and HBV infection (P<0.05). Serum IL-17 and IL-18 levels were positively correlated with serum AST and ALT levels in patients with IgA nephropathy and HBV infection (P<0.05).Conclusion IgA nephropathy patients with HBV infection have abnormal expressions of serum IL-17 and IL-18, and the degree of abnormality is closely related to HBV-DNA load. The dynamic changes of the above serum indexes can timely reflect the HBV infection and liver func.tion changes in patients with IgA nephropathy. |
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