| 秦百君,陈月桥,彭晓鹏,等.中药多途径治疗急性胰腺炎并发腹间隔室综合征疗效评价:一项荟萃分析[J].安徽医药,2022,26(12):2333-2340. |
| 中药多途径治疗急性胰腺炎并发腹间隔室综合征疗效评价:一项荟萃分析 |
| Evaluation on Chinese medicine in the treatment of acute pancreatitis complicated with abdominal compartment syndrome: an meta analysis |
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| DOI：10.3969/j.issn.1009-6469.2022.12.001 |
| 中文关键词: 胰腺炎 腹间隔室综合征 中草药 综述 荟萃分析 |
| 英文关键词: Pancreatitis Abdominal syndrome Drugs, Chinese herbal Review Meta-analysis |
| 基金项目:广西壮族自治区推广应用项目( S2019021)；广西科技基地和人才专项项目(桂科 AD17129001)；广西中医药大学博士研究生创新项目( YCBXJ2021010) |
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| 中文摘要: |
| 目的系统评价中药多途径治疗急性胰腺炎并发腹间隔室综合征疗效。方法检索中国知网、万方、维普、 Sinomed、 PubMed、Embase、Cochrane Library自建库至 2020年 12月 1日收录的中医药治疗急性胰腺炎并发腹间隔室综合征的临床试验， RevMan5.3软件进行荟萃分析。结果共纳入 17项研究，共 1 033例病人；荟萃分析显示，与西药基础治疗比较，中西药联用可显著降低腹内压［标准化均数差( SMD)95%CI:.0.63(.0.83，0.43)］；与西药基础治疗比较，联用中药组可显著降低急性生理学和慢性健康状况评价 Ⅱ(APACHE Ⅱ)评分［ SMD 95%CI:.0.65(.0.87，0.43)］；与西药基础治疗比较，联用中药组可有效缩短排便恢复时间［ SMD 95%CI:.0.68(.1.14，0.22)］；此外，小样本的研究表明中西医结合相较于单纯西药治疗可降低病人死亡情况［比值比( OR)95%CI:1.04(.1.91，.0.16)］。结论中药治疗急性胰腺炎并发腹间隔室综合征可降低腹内压、减少临床 APACHE Ⅱ评分、缩短病人排便恢复时间。 |
| 英文摘要: |
| Objective To systematically evaluate the therapeutic effect of traditional Chinese medicine on acute pancreatitis compli.cated with abdominal compartment syndrome.Methods The randomized controlled trials of Chinese medicine combined with Western medicine in the treatment of acute pancreatitis complicated with abdominal compartment syndrome were retrieved from CNKI, Wan.fang, VIP, sinomed, PubMed, EMBASE and Cochrane library. Revman5.3 and stata16.0 were used for bias evaluation and meta-analy. sis, and TSA 0.9.5.10 was used for sequential analysis.Results A total of 17 studies with 1 033 patients were included. Meta-analysisshowed that compared with the Western medicine, the combination of Chinese and Western medicines significantly reduced intra-ab. dominal pressure [SMD 95%CI:.0.63 (.0.83, 0.43)] and APACHE Ⅱ scores [SMD 95%CI:.0.65 (.0.87, 0.43)], and the combination of Chinese herbal medicine was effective in reducing the recovery time of defecation [SMD 95%CI:.0.68 (.1.14,0.22)]. In addition, asmall sample of studies showed that the combination of Chinese and Western medicine reduced the death of patients compared with thetreatment with Western medicine alone [OR 95%CI:1.04 (.1.91, .0.16)].Conclusion Chinese medicine can reduce intra-abdominal pressure, APACHE Ⅱ score and defecation recovery time. |
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