| 郑惠文,刘永海,陈雪婷,等.脑微出血病人血清 β淀粉样蛋白 1-42、磷酸化 τ-181蛋白的检测意义[J].安徽医药,2022,26(12):2403-2406. |
| 脑微出血病人血清 β淀粉样蛋白 1-42、磷酸化 τ-181蛋白的检测意义 |
| Clinical significance of detecting serum Aβ1-42 and phosphorylated tau-181 protein in patients with cerebral microbleeds |
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| DOI：10.3969/j.issn.1009-6469.2022.12.015 |
| 中文关键词: 大脑小血管疾病 淀粉样 β肽类 磷酸化 τ-181蛋白 认知功能 |
| 英文关键词: Cerebral small vessel diseases Amyloid beta-peptides Phosphorylated tau-181 protein Cognitive function |
| 基金项目:国家自然科学基金项目( 81501095) |
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| 中文摘要: |
| 目的探讨脑微出血病人血清 β淀粉样蛋白 1-42(Aβ1-42)、磷酸化 τ-181蛋白检测的意义。方法收集 2019年 11月至 2020年 5月在徐州医科大学附属医院经头颅磁共振成像( MRI)+磁敏感加权成像( SWI)检查证实存在脑微出血的腔隙性脑梗死病人 50例为研究组，与之性别、年龄相匹配的不存在脑微出血的腔隙性脑梗死病人 50例为对照组。将研究组按照脑微出血的 MARS评估量表分为皮层和皮质下组( 16例)、深部组( 14例)、幕下组( 15例)和混合组( 5例)。对比各组间血清 Aβ1-42、磷酸化 τ-181蛋白浓度。结果与对照组( 36.63±12.72)ng/L相比，研究组血清 Aβ1-42浓度( 50.14±25.75)ng/L明显升高( P<0.05)；对照组( 17.82±6.93)ng/L相比，研究组血清 τ-181浓度( 26.40±12.24)ng/L明显升高( P<0.05)。且脑微出血总数目与血清 Aβ1-42与 |
| 英文摘要: |
| Objective To investigate the significance of serum β-amyloid 1-42 (Aβ1-42) and phosphorylated tau-181 protein detec. tion in patients with cerebral microbleeds (CMBs).Methods A total of 50 patients with lacunar infarction who were confirmed to havecerebral microbleed by cranial magnetic resonance imaging (MRI) + magnetic susceptibility weighted imaging (SWI) at the AffiliatedHospital of Xuzhou Medical University from November 2019 to May 2020 were collected as the research group, and 50 patients with la.cunar cerebral infarction who were matched for sex and age without cerebral microbleed were selected as the control group. Accordingto the MARS assessment scale for cerebral microbleeds, the research group was divided into cortical and subcortical group (16 cases),deep regions (14 cases), infratentorial regions (15 cases), and mixed regions (5 cases). The serum Aβ1-42 and phosphorylated tau-181 pro. tein concentrations between the groups were compared.Results The serum Aβ1-42 concentration (50.14±25.75) ng/L was significant. ly higher in the research group than in the control group (36.63±12.72) ng/L (P<0.05); the serum tau-181 concentration (26.40± 12.24) ng/L was significantly higher in the research group than in the control group (17.82±6.93) ng/L (P<0.05), and the total number of CMBs was positively correlated with both serum Aβ1-42 and serum phosphorylated tau-181 concentrations (r=0.46, 0.30, P<0.05). How. ever, the differences in serum Aβ1-42 and phosphorylated tau-181 concentrations between the cortical and subcortical groups, the deepgroup, and the infratentorial regions group were not statistically significant (P>0.05).Conclusion The mechanism of the effect of cere. bral microbleeds on cognitive function was positively correlated with serum Aβ1-42 and phosphorylated tau-181 protein, and it is clinical. ly important to detect serum Aβ1-42 and phosphorylated tau-181 protein in CMBs patients with potential cognitive impairment. |
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