| 薛洁,张利玲,霍晓燕,等.不同孕期血清中维生素 A、D、E水平变化及其与妊娠期高血糖的关系[J].安徽医药,2022,26(12):2406-2411. |
| 不同孕期血清中维生素 A、D、E水平变化及其与妊娠期高血糖的关系 |
| Changes in serum levels of vitamin A, D and E in different gestational periods and their relationship with gestational hyperglycemia during pregnancy |
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| DOI：10.3969/j.issn.1009-6469.2022.12.016 |
| 中文关键词: 妊娠并发症 高血糖症 维生素 A 维生素 D 维生素 E 25-羟维生素 D2 骨化二醇 糖尿病，妊娠 妊娠初期 妊娠中期 妊娠末期 孕妇 |
| 英文关键词: Pregnancy complications Hyperglycemia Vitamin A Vitamin D Vitamin E 25-Hydroxyvitamin D2 Cal. cifediol Diabetes, gestational Early pregnancy Middle pregnancy Late pregnancy Pregnant women |
| 基金项目:河北省医学科学研究课题计划项目( 20191806) |
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| 中文摘要: |
| 目的检测不同妊娠期的高血糖病人和健康孕妇的血清维生素 A、D、E水平，并分析其与妊娠期高血糖的相关性。方法回顾性分析邯郸市第一医院 2018年 1月至 2019年 5月收治的 84例妊娠期高血糖病人的孕期资料，记为疾病组；另采用抽签法回顾性分析 84例健康孕妇的孕期资料，记为对照组。两组均分别于孕早期、孕中期、孕晚期检测血清维生素 A、 25-羟维生素 D(25-OH-D)及其分型［ 25-羟维生素 D(225-OH-D2)和 25-羟维生素 D3)］、(25-OH-D3维生素 E水平。采用 logistic回归分析探讨妊娠期高血糖的影响因素。结果疾病组孕早期血清 25-OH-D、25-OH-D2、25-OH-D3水平分别为( 28.75±4.06) μg/L、(9.52±1.28)μg/L、(15.32±2.07)μg/L，孕中期为( 26.52±3.85)μg/L、(8.95±1.15)μg/L、(13.21±2.02)μg/L，孕晚期为(21.05±3.75)μg/L、(7.15±1.08)μg/L、(11.25±1.85)μg/L。对照组孕早期分别为( 59.63±8.14)μg/L、(15.86±2.45)μg/L、(30.08±6.25)μg/L，孕中期为( 55.48±7.12)μg/L、(14.52±2.32)μg/L、(29.58±6.40)μg/L，孕晚期为( 51.28±6.56)μg/L、(13.56±2.04)μg/ L、(27.15±6.21)μg/L。疾病组不同孕期血清 25-OH-D、25-OH-D2、25-OH-D3水平均低于对照组(均 P<0.05)；两组孕早期、孕中期、孕晚期血清维生素 A、维生素 E对比差异无统计学意义(均 P>0.05)；疾病组糖尿病家族史、孕前肥胖、孕早期 25-OH-D缺乏、孕早期 25-OH-D2缺乏、孕早期 25-OH-D3缺乏、孕中期 25-OH-D缺乏、孕中期 25-OH-D2缺乏、孕中期 25-OH-D3缺乏、孕晚期 25-OH-D缺乏、孕晚期 25-OH-D2缺乏、孕晚期 25-OH-D3缺乏构成比分别为 14.29%、33.33%、53.57%、48.81%、53.57%、57.14%、53.57%、50.00%、60.71%、55.95%、58.33%，对照组分别为 1.19%、5.95%、8.33%、7.14%、5.95%、11.90%、9.52%、11.90%、14.29%、11.90%、9.52%，疾病组均高于对照组(均 P<0.05)经 logistic回归分析证实均为妊娠期高血糖的独立危险因素( P<0.05)；疾病组孕早期 25-OH-D正常、孕早期 25-OH-D2正常、早期 25-OH-D3正常、孕中期 25-OH-D正常、孕中期 25-OH-D2正常、孕中期 25-OH-D3正常、孕晚期 25-OH-D正常、孕晚期 25-OH-D2正常、孕晚期 25-OH-D3正常构成比均低于对照组(均 P<0.05)。结论妊娠期高血糖病人孕早期、孕中期、孕晚期血清 25-OH-D、25-OH-D2、25-OH-D3水平均偏低，且糖尿病家族史、孕前肥胖和 25-OH-D、25-OH-D2、25-OH-D3缺乏均是妊娠期高血糖的独立危险因素。孕， |
| 英文摘要: |
| Objective The levels of serum vitamin A, D, and E in patients with hyperglycemia in different gestational periods andhealthy pregnant women were detected, and their correlation with hyperglycemia in pregnancy was analyzed.Methods The pregnancydata of 84 patients with gestational hyperglycemia admitted to the First Hospital of Handan City from January 2018 to May 2019 wereretrospectively analyzed and recorded as the disease group; the pregnancy data of 84 healthy pregnant women were also retrospectivelyanalyzed using the lottery method and recorded as the control group. Serum vitamin A, 25-hydroxyvitamin D (25-OH-D) and its frac. tions [25-hydroxyvitamin D2 (25-OH-D2) and 25-hydroxyvitamin D3 (25-OH-D3)] and vitamin E levels were measured in both groups inearly, mid and late pregnancy, respectively. Logistic regression analysis was used to explore the influencing factors for gestational hy.perglycemia.Results The serum levels of 25-OH-D, 25-OH-D2 and 25-OH-D3 in early pregnancy in the disease group were 28.75±4.06 μg/L, 9.52±1.28 μg/L, and 15.32±2.07 μg/L, 26.52±3.85 μg/L, 8.95±1.15 μg/L, and 13.21±2.02 μg/L in middle pregnancy, and21.05±3.75 μg/L, 7.15±1.08 μg/L, and 11.25±1.85 μg/L in late pregnancy, respectively. The serum levels of 25-OH-D, 25-OH-D2 and 25-OH-D3 in early pregnancy in the control group were 59.63±8.14 μg/L, 15.86±2.45 μg/L, and 30.08±6.25 μg/L, respectively, andwere 55.48±7.12 μg/L, 14.52±2.32 μg/L, and 29.58±6.40 μg/L in middle pregnancy, and were 51.28±6.56 μg/L, 13.56±2.04 μg/L,and 27.15±6.21 μg/L in late pregnancy, respectively. The serum levels of 25-OH-D, 25-OH-D2 and 25-OH-D3 in different pregnancy stages in the disease group were lower than those in the control group (P<0.05). There was no statistically significant difference in se.rum vitamin A and vitamin E levels between the two groups in early, middle and late pregnancy (P>0.05). The composition ratios of family history of diabetes mellitus, prepregnancy obesity, 25-OH-D, 25-OH-D2 and 25-OH-D3 deficiency in early, middle, and late preg.nancy in the disease group were 14.29%, 33.33%, 53.57%, 48.81%, 53.57%, 57.14%, 53.57%, 50.00%, 60.71%, 55.95%, 58.33%, re.spectively, which were higher than those in the control group (1.19%, 5.95%, 8.33%, 7.14%, 5.95%, 11.90%, 9.52%, 11.90%, 14.29%,11.90%, 9.52%, respectively) (P<0.05) and were confirmed by logistic regression analysis to be independent risk factors for gestational hyperglycemia (P<0.05). In the disease group, the rates of normal 25-OH-D, 25-OH-D2 and 25-OH-D3in early, middle and late pregnan. cy were lower than those in the control group (P<0.05).Conclusion Patients with gestational hyperglycemia had low serum 25-OH-D, 25-OH-D2, and 25-OH-D3 levels in early, mid, and late pregnancy, and a family history of diabetes, prepregnancy obesity, and 25-OH-D, 25-OH-D2, and 25-OH-D3 deficiency were all independent risk factors for gestational hyperglycemia. |
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