| 陆雨纯,沃眉宏,周晓燕,等.单核细胞 /高密度脂蛋白比值与 2型糖尿病周围神经病变的相关性研究[J].安徽医药,2022,26(12):2425-2429. |
| 单核细胞 /高密度脂蛋白比值与 2型糖尿病周围神经病变的相关性研究 |
| Research on the correlation between monocyte to high-density lipoprotein cholesterol ratio and diabetic peripheral neuropathy in type 2 diabetes mellitus |
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| DOI：10.3969/j.issn.1009-6469.2022.12.020 |
| 中文关键词: 糖尿病神经病变 糖尿病， 2型 单核细胞 /高密度脂蛋白比值 神经传导速度 腓肠神经 胫神经 |
| 英文关键词: Diabetic neuropathies Diabetes mellitus,type 2 Monocyte to high-density lipoprotein cholesterol ratio Nerve con. duction velocity Sural nerve Tibial nerve |
| 基金项目:中国博士后科学基金( 2019M651970) |
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| 中文摘要: |
| 目的探讨单核细胞 /高密度脂蛋白比值( MHR)与 2型糖尿病周围神经病变( DPN)的相关性。方法选取 2018年 8月至 2021年 3月在徐州医科大学附属医院住院的 2型糖尿病病人 431例，其中未并发 DPN病人 183例(对照组)，并发 DPN病人 248例( DPN组)。收集以上两组病人一般临床资料，检测空腹血糖、糖化血红蛋白( HbA1c)、 C肽、血常规、血脂、生化、尿微量白蛋白等指标，计算 MHR，利用肌电图测定所有对象下肢神经传导速度及 F波潜伏期。采用多因素 logistic回归分析探讨糖尿病病人并发 DPN的影响因素，采用受试者操作特征曲线( ROC曲线)分析 MHR对糖尿病病人并发 DPN的预测价值。结果 DPN组的糖尿病视网膜病变、糖尿病肾病、糖尿病足人数所占比例、年龄、病程、尿酸、胱抑素 C、右胫神经 F波潜伏期、单核细胞、高密度脂蛋白胆固醇、右腓总神经传导速度、右腓肠神经传导速度与对照组比较，均差异有统计学意义( P<0.05)。 DPN组的 MHR水平［ 3.60(2.61，4.71)］ ×109/mmol明显高于对照组［ 0.28(0.21，0.34)］ ×109/mmol，差异有统计学意义( P<0.001)。多重 logistic回归分析显示，年龄、病程、糖尿病视网膜病变、尿酸、 MHR为病人发生周围神经病变的影响因素( P<0.05)。 Spearman相关性分析结果显示， MHR与右腓总神经传导速度、右腓肠神经传导速度呈负相关，与右胫神经 F波潜伏期呈正相关。通过 ROC曲线检测， MHR的 AUC面积、截断值分别是为 0.703、0.312，特异度和灵敏度分别为 65.6%、66.9%。结论 MHR在 DPN病人中呈高水平， MHR血清水平有望用于临床上 DPN的风险评估和预测 |
| 英文摘要: |
| Objective To investigate the relationship between monocyte to high-density lipoprotein cholesterol ratio (MHR) and dia. betic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM).Methods A total of 431 T2DM patients were recruited fromDepartment of Endocrinology, The Affiliated Hospital of Xuzhou Medical University from August 2018 to March 2021, among whomthere were 248 with DPN (DPN group) and 183 without DPN (simple group). The general data of the patients were recorded. The indi.ces of the two groups, such as fasting blood-glucose, glycosylated hemoglobin (HbA1c), C peptide, blood cell count, blood chemistries,blood fat, urine microalbumin were examined. MHR level was calculated. Lower limbs nerve conduction velocity and F wave latencywere measured using electromyographic characteristics (EMG). Binary logistic regression analysis was carried out to identify the factorsassociated with DPN. Receiver operating characteristic (ROC) curve analysis was adopted to analyze the predictive value of MHR ratiofor DPN.Results The proportions of diabetic retinopathy, diabetic kidney disease and diabetic foot, age, course of disease, uric acid,cystatin C, right tibial nerve F wave latency, monocytes, high-density lipoprotein cholesterol, right common peroneal nerve conductionvelocity and right sural nerve conduction velocity were all statistically different between in the DPN group and the simple group (P< 0.05). The MHR level in the DNP group [3.60 (2.61, 4.71)]×109/mmol was higher than that in the simple group [0.28 (0.21, 0.34)]×109/mmol (P<0.001). Multiple logistic regression analysis showed that age, course of disease, diabetic retinopathy, uric acid, and MHRwere influence factors that affected patients with DPN (P<0.05). The result of Spearman correlation analysis showed that there was anegative correlation between MHR and right common peroneal nerve conduction velocity and right sural nerve conduction velocity, and positive correlation with right tibial nerve F wave latency. According to ROC curve, the AUC area and cut-off value of MHR were 0.703 and 0.312, and the specificity and sensitivity were 65.6% and 66.9%, respectively.Conclusion The level of MHR in patients with DPNis significantly increased. The detection of the MHR ratio is expected to be applied to clinical risk assessment and prediction of DPN. |
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