| 张琼果,徐璐,李莉,等.肿瘤细胞周期相关蛋白在肾移植术后弥漫大 B细胞淋巴瘤中的表达及与预后的关系[J].安徽医药,2022,26(12):2497-2501. |
| 肿瘤细胞周期相关蛋白在肾移植术后弥漫大 B细胞淋巴瘤中的表达及与预后的关系 |
| Expression of tumor cell cycle-related proteins in diffuse large B-cell lymphoma after renal transplantation and its relationship with prognosis |
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| DOI：10.3969/j.issn.1009-6469.2022.12.036 |
| 中文关键词: 淋巴瘤，大 B细胞，弥漫性 利妥昔单抗 肾移植 肿瘤细胞周期相关蛋白 预后 |
| 英文关键词: Lymphoma, large B cell, diffuse Rituximab Renal transplantation Tumor cell cycle-associated protein Prognosis |
| 基金项目:海南省自然科学基金青年基金项目( 820QN401) |
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| 中文摘要: |
| 目的探讨肿瘤细胞周期相关蛋白( CREPT)在肾移植术后弥漫大 B细胞淋巴瘤( DLBCL)中的表达及与预后的关系研究。方法选择 2013年 2月至 2019年 8月海南医学院第一附属医院、海南省肿瘤医院、海南医学院第二附属医院收治的 40例肾移植术后发生 DLBCL的病人作为研究对象，以病灶组织作为病例组；另外选择 50例增生性淋巴结炎组织作为对照组。采用免疫组化方法检测组织 CREPT表达情况，收集肾移植术后 DLBCL病人的临床资料，分析临床资料、治疗效果、预后与 CREPT表达的关系。结果 CREPT定位于细胞核或细胞质， 40例肾移植术后发生 DLBCL病人中 CREPT高表达者 23例( 57.50%)50例增生性淋巴结炎组织中高表达者 5例( 10.00%)(P<0.05)。 CREPT高表达组 EB活化率高于低表达组，高 Ann Arboe分期病人，比例高于 CREPT低表达组( P<0.05)。达到有效标准病人 36例，多因素分析示， Ann Arboe分期是治疗效果的影响因素( P< |
| 英文摘要: |
| Objective To investigate the expression of tumor cell cycle-related proteins (CREPTs) in diffuse large B-cell lymphoma (DLBCL) after renal transplantation and the relationship with prognosis.Methods Forty patients who developed DLBCL after kidneytransplantation admitted to the First Affiliated Hospital of Hainan Medical College, Hainan Cancer Hospital and the Second AffiliatedHospital of Hainan Medical College from February 2013 to August 2019 were selected as the study subjects, and the lesion tissues wereused as the case group. In addition, 50 cases of hyperplastic lymphadenitis tissues were selected as the control group. The expression ofCREPT was detected by immunohistochemical method, and clinical data of DLBCL patients after renal transplantation were collectedto analyze the relationship between clinical data, treatment effect, prognosis and CREPT expression.Results CREPT was localized in the nucleus or cytoplasm of cells. Twenty-three of 40 patients (57.50%) with DLBCL after renal transplantation and 5 of 50 patients(10.00%) with hyperplastic lymphadenitis tissues had high expression of CREPT (P<0.05). The rate of EB activation was higher in thegroup with high CREPT expression than that in the group with low expression, and the proportion of patients with high Ann Arboe stagewas higher than in the group with low CREPT expression (P<0.05). There were 36 patients who met the effective criteria. Multivariateanalysis showed that Ann Arboe stage was an influential factor in treatment outcome (P<0.05). The overall survival time was significant.ly lower in the group with high CREPT expression than in the group with low expression (P<0.05); the difference in progression-free sur. vival between the two groups was not statistically significant (P>0.05). The Cox multivariate analysis showed that Ann Arboe stage and treatment response were associated with progression-free survival regression (P<0.05). Reduced transplant renal function, Ann Arboestage, physical performance score (ECOG), treatment response, and CREPT expression were correlated with overall survival (P<0.05). Conclusion The expression level of CREPT was higher in DLBCL patients after renal transplantation and was associated with theclinical characteristics and prognosis of the patients. |
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