| 田雨,谭兴,王振振,等.原发免疫性血小板减少症病人静脉血栓形成的临床特点及危险因素分析[J].安徽医药,2023,27(1):92-96. |
| 原发免疫性血小板减少症病人静脉血栓形成的临床特点及危险因素分析 |
| Clinical characteristics and risk factors analysis of venous thrombosis in patients with primary immune thrombocytopenia |
| |
| DOI：10.3969/j.issn.1009-6469.2023.01.020 |
| 中文关键词: 原发免疫性血小板减少症 静脉血栓 危险因素 嘧啶二聚物 受体，血小板生成素 |
| 英文关键词: Primaryimmunethrombocytopenia Venousthrombosis Riskfactors Pyrimidinedimers Receptors,thrombopoietin |
| 基金项目:山东省自然科学基金( ZR2020KH023) |
|
| 摘要点击次数: 1683 |
| 全文下载次数: 604 |
| 中文摘要: |
| 目的分析原发免疫性血小板减少症(ITP)病人静脉血栓形成的临床特点及相关危险因素，为临床提供诊疗依据。方法对 2016年 3月至 2021年 6月山东中医药大学附属医院血液科收治的 174例 ITP病人进行回顾性分析。结果共 15例病人发生静脉血栓事件，发病率约为 8.57%，以下肢深静脉栓塞为主。男性静脉血栓发病率高于女性(66.7%比 33.3%)，血栓组的年龄与体质量指数(BMI)均高于非血栓组(P=0.007，0.001)。静脉血栓发生的中位时间为确诊 ITP后的 13个月，确诊静脉血栓时的血小板中位计数(56×109/L)高于确诊 ITP时的中位计数(37×109/L)血栓事件发生时 15例病人的血小板均小于 100×109/L。多因素逻辑回归分析结果显示血小板(P=0.013)D-二聚体( P=0.008)、，癌症(P=0.006)、血小板生成素受体激动剂( thrombopoietin receptor agonist，TPO-RA)(P=0.027)是血栓形成、的危险因素。结论静脉血栓可能形成于血小板升高的阶段；血小板、 D-二聚 |
| 英文摘要: |
| Objective To analyze the clinical characteristics and related risk factors of venous thrombosis in patients with primaryimmune thrombocytopenia (ITP), so as to provide clinical diagnosis and treatment.Methods One hundred and seventy-four patientswith ITP admitted to the Department of Hematology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine fromMarch 2016 to June 2021 were retrospectively analyzed.Results A total of 15 patients had venous thrombosis events, the incidencewas about 8.57%, mainly deep venous embolism of lower limbs. The incidence of venous thrombosis in males was higher than that in females (66.7% vs. 33.3%), and the age and body mass index (BMI) of the thrombus group were higher than those in the non-thrombus group (P=0.007, 0.001). The median time of occurrence of venous thrombosis was 13 months after the diagnosis of ITP, and the medianplatelet count at the time of diagnosis of venous thrombosis (56×109/L) was higher than that at the time of diagnosis of ITP (37×109/L). Platelets in all 15 patients were less than 100×109/L at the time of thrombosis events. Multivariate logistic regression analysis showed that platelet (P=0.013), D-dimer (P=0.008), cancer (P=0.006) and thrombopoietin receptor agonist (TPO-RA) (P=0.027) were risk factors for thrombosis.Conclusion Venous thrombosis may be formed at the stage of elevated platelets; platelets, D-dimer, cancer, and TPO-RA are independent risk factors for venous thrombosis in patients with ITP. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
