| 李洋,李旵灿,夏梦,等.特发性弱精症病人精液理化特征、精子发生及形态学参数的相关性探讨[J].安徽医药,2023,27(1):96-99. |
| 特发性弱精症病人精液理化特征、精子发生及形态学参数的相关性探讨 |
| Correlation of semen physical and chemical characteristics, spermatogenesis and morphological parameters in patients with idiopathic asthenospermia |
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| DOI：10.3969/j.issn.1009-6469.2023.01.021 |
| 中文关键词: 弱精子症 不育，男(雄)性 畸形精子症 |
| 英文关键词: Asthenozoospermia Infertility, male Teratozoospermia |
| 基金项目:安徽省自然科学基金青年项目( 1808085QH240)；安徽高校自然科学基金项目( KJ2019A1104) |
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| 中文摘要: |
| 目的探讨特发性弱精症病人精液理化特征、精子发生及形态学参数的相关性，为全面评估和治疗弱精症提供依据。方法回顾性分析 2019年 10月至 2020年 10月安徽省第二人民医院生殖医学中心就诊的 412例男性受试者，按精子活力分为正常组(282例)轻中度弱精组(104例)、重度弱精组(24例)、极重度弱精组(2例)，分别检测各组标本精液理化特征参数(精液体积、液化时间、 p、H)、精子发生参数(精子浓度、精子总数、活动精子总数)和精子形态学参数(正常形态率、畸形精子指数、精子畸形指数)等指标，分析不同活力组间各参数相关性。结果与正常组相比，轻中度和重度弱精病人精液 pH下降，液化时间延长，正常形态率显著降低［( 5.09±1.93)%、(3.43±1.42)%比( 5.63±2.02)%］，其中头部形态异常率［( 93.41±3.09)%、(96.21± |
| 英文摘要: |
| Objective To investigate the correlation of semen physicochemical characteristics, spermatogenesis and morphologicalparameters in patients with idiopathic asthenospermia, so as to provide basis for comprehensive evaluation and treatment of astheno‐spermia.Methods Four hundred and twelve male subjects in the reproductive medicine center of Anhui No.2 People′s Hospital fromOctober 2019 to October 2020 were retrospectively analyzed. They were assigned into normal group (282 cases), mild to moderate asthenospermia group (104 cases), severe asthenospermia group (24 cases) and very severe asthenospermia group (2 cases) according tosperm motility. The semen physical and chemical parameters (semen volume, liquefaction time, pH), spermatogenesis parameters(sperm concentration, total sperm count, total motile sperm count) and sperm morphological parameters (normal morphological rate, teratozoospermia index and sperm deformity index) were detected, in the meantime, the correlation of each parameter between different vitality groups was analyzed.Results Compared with the normal group, the semen pH of mild to moderate and severe asthenospermia patients decreased, the liquefaction time prolonged, the normal morphology rate decreased significantly (5.09±1.93)%, (3.43±1.42)% vs. (5.63±2.02)%, and the abnormal rate of head segment (93.41±3.09)%, (96.21±1.67)% vs. (92.79±2.69)% had significant difference. Conclusion Sperm motility parameters such as sperm concentration and total sperm count in patients with idiopathic asthenospermiaare significantly lower than those in normal people, and sperm deformity rate is significantly increased, and the two are correlated,which is of great significance for comprehensive evaluation of patients′ semen quality and selection of assisted reproductive methods. |
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