| 王林,黄瓅,窦学军.老年晚期肺癌并发急性非大面积肺栓塞的高危因素分析[J].安徽医药,2023,27(1):100-103. |
| 老年晚期肺癌并发急性非大面积肺栓塞的高危因素分析 |
| High risk factors of acute non-large-area pulmonary embolism in elderly patients with advanced lung cancer |
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| DOI：10.3969/j.issn.1009-6469.2023.01.022 |
| 中文关键词: 肺肿瘤 肺栓塞 高危因素 血红蛋白类 因果律 老年人 |
| 英文关键词: Lung neoplasms Pulmonary embolism High risk factors Hemoglobins Causality Aged |
| 基金项目:首都医学发展科研基金( 2017-1713) |
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| 中文摘要: |
| 目的分析老年晚期肺癌急性非大面积肺栓塞的高危因素。方法选择 2016年 1月至 2019年 5月在长沙市第三医院治疗的老年肺癌病人 220例作为研究对象，根据是否合并急性非大面积肺栓塞，分为肺癌组和合并肺栓塞组。统计肺癌病人合并急性非大面积肺栓塞的发生情况，采用单因素分析影响老年晚期肺癌急性非大面积肺栓塞的相关因素；采用多因素 logistic回归分析影响老年晚期肺癌急性非大面积肺栓塞的危险因素。调查因素包括性别、年龄、体质量指数( BMI)、吸烟史、手术史、肺栓塞病史、病理类型、肿瘤分期( tumor node metastasis classification，TNM)、中心静脉穿刺置管、辅助化疗、血红蛋白、 D-二聚体、癌胚抗原。结果纳入的老年晚期肺癌病人 220例中，合并急性非大面积肺栓塞 62例，发生率为 28.18%。经单因素分析结果显示，两组性别、年龄、 BMI、手术史、肺栓塞史、中心静脉穿刺置管、 D-二聚体和癌胚抗原水平比较差异无统计学意义(P >0.05)；两组有吸烟史( 38.46%比 61.54%)、病理类型腺癌( 44.19%比 55.81%)、 TNM分期 Ⅳ期( 43.42%比 56.58%)、有辅助化疗 |
| 英文摘要: |
| Objective To explore the high risk factors of acute non-large-area pulmonary embolism in elderly patients with advanced lung cancer.Methods The 220 elderly patients with lung cancer who were treated in Changsha Third Hospital from January2016 to May 2019 were selected as the study objects. According to whether they had concurrent acute non-large-area pulmonary embolism, they were assigned into lung cancer group and concurrent pulmonary embolism group. Statistical analysis was made of the incidence of lung cancer patients with concurrent acute non-large-area pulmonary embolism. Single factor analysis was made of the relevant influencing factors, and multifactor Logistic regression analysis was made of the risk factors. The investigation factors includedgender, age, body mass index (BMI), smoking history, operation history, pulmonary embolism history, pathological type, TNM staging,central vein catheterization, adjuvant chemotherapy, hemoglobin, D-dimer, and carcinoembryonic antigen.Results Among the included 220 elderly patients with advanced lung cancer, 62 (28.18%) were complicated with acute non-large-area pulmonary embolism. Theresults of univariate analysis showed that there were no significant differences in gender, age, BMI, operation history, pulmonary embolism history, central venous catheterization, D-dimer and carcinoembryonic antigen level between the two groups (P>0.05); there were significant differences in history of smoking (38.46% vs. 61.54%), pathological type of adenocarcinoma (44.19% vs. 55.81%), TNM stage IV (43.42% vs. 56.58%), adjuvant chemotherapy (38.89% vs. 61.11%) and hemoglobin level<140 g/L (41.84% vs. 58.16%) The results of multivariate analysis showed that smoking history, pathological type, TNM staging, adjuvant chemotherapy and hemoglobinwere the risk factors for the concurrent acute non-large-area pulmonary embolism of the elderly patients with advanced lung cancer. Conclusion There are many risk factors for the concurrent acute non-large-area pulmonary embolism of the elderly patients with ad vanced lung cancer, and patients with long-term smoking, adenocarcinoma, high TNM staging, adjuvant chemotherapy and increasedhemoglobin should be alert to the occurrence of acute non-large-area pulmonary embolism. It is vital to strengthen the early screeningof pulmonary embolism, and give preventive anticoagulation treatment. |
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