| 薛颖,杨艳景,闫娟,等.补肾活血散瘀汤联合高强度聚焦超声对子宫腺肌病的疗效及病人免疫功能的影响[J].安徽医药,2023,27(1):131-134. |
| 补肾活血散瘀汤联合高强度聚焦超声对子宫腺肌病的疗效及病人免疫功能的影响 |
| Efficacy of Bushen Huoxue Sanyu decoction combined with high-intensity focused ultrasound on adenomyosis and its influence on the immune function of patients |
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| DOI：10.3969/j.issn.1009-6469.2023.01.029 |
| 中文关键词: 子宫腺肌病 高强度聚焦超声 补肾活血散瘀汤 免疫功能 月经 补体 C3 免疫球蛋白类 |
| 英文关键词: Adenomyosis High-intensity focused ultrasound Bushen Huoxue Sanyu decoction Immune function Menstruation Complement C3 Immunoglobulins |
| 基金项目:石家庄市科学技术研究与发展计划( 201460893) |
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| 中文摘要: |
| 目的探究补肾活血散瘀汤联合高强度聚焦超声对子宫腺肌病的疗效及病人免疫功能的影响。方法选取 2020年 7—12月石家庄市人民医院收治的 110例子宫腺肌病病人，按随机数字表法分为超声组( 55例)和联合组( 55例)。其中超声组给予高强度聚焦超声治疗，联合组给予补肾活血散瘀汤联合高强度聚焦超声治疗子宫腺肌病病人。比较两组病人免疫功能［补体 C3、C4、免疫球蛋白 A(IgA)、免疫球蛋白 G(IgG)、免疫球蛋白 M(IgM)］，月经改善情况(月经量、疼痛程度)中医症候积分，血清糖类抗原 CA125水平、子宫体积及不良反应发生情况。结果与治疗前比较，两组治疗后补体 C3［联合，组( 95.32±2.12)比( 102.74±3.42)mg/dL、超声组( 98.12±2.58)比( 101.89±3.36)mg/dL］、 IgA水平［联合组( 2.42±0.26)比( 3.47±0.46)mg/dL、超声组( 3.01±0.34)比( 3.54±0.51)g/L］、月经量评分、疼痛视觉模拟评分法( VAS评分)、中医症候积分、血清糖类抗原 CA125水平、子宫体积明显降低( P<0.05)且与超声组比较，联合组明显降低( P<0.05)；两组血清 IgG［联合组( 15.78±1.67)比( 12.12±1.14)g/L、超声组( 13.78±1.42)比.35±1.21)g/L］明显升高( P<0.05)，且与超声组比较，联合组明显升高( P<0.05)两组不良反应发生率比较差异无统计学意义( P>0.05)。结论补肾活血散瘀汤联合高强度聚焦超声治疗子宫腺肌病病人可有效改善临(12，床症状，提高免疫功能，安全有效。 |
| 英文摘要: |
| Objective To explore the efficacy of Bushen Huoxue Sanyu decoction combined with high-intensity focused ultrasound on adenomyosis and its influence on the immune function of patients.Methods A total of 110 patients with adenomyosis admitted toShijiazhuang People′s Hospital from July 2020 to December 2020 were randomly assigned into ultrasound group (55 cases) and combination group (55 cases) according to random number table method. The ultrasound group was given high-intensity focused ultrasound therapy, while the combination group was given Bushen Huoxue Sanyu decoction combined with high-intensity focused ultrasound. Theimmune function [complement C3, C4, immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM)], menstrual improvement (menstrual volume, pain degree), TCM symptom score, serum carbohydrate antigen CA125 level, uterine volume and adversereactions were compared between the two groups.Results Compared with before treatment, the complement C3 [combination group: (95.32±2.12) mg/dL vs. (102.74±3.42) mg/dL; ultrasound group: (98.12±2.58) mg/dL vs. (101.89±3.36) mg/dL], level of IgA [combination group: (2.42±0.26) mg/dL vs. (3.47±0.46) mg/dL; ultrasound group: (3.01±0.34) g/L vs. (3.54±0.51) g/L], menstrual volume score,visual analogue scale of pain (VAS score), TCM syndrome score, serum carbohydrate antigen CA125 level, and uterine volume were significantly reduced after treatment in the two groups (P<0.05), and compared with the ultrasound group, those in the combination group were significantly lower (P<0.05). The levels of serum IgG [combination group: (15.78±1.67) g/L vs. (12.12±1.14) g/L; ultrasound group: (13.78±1.42) g/L vs. (12.35±1.21) g/L] in the two groups were significantly increased (P<0.05), and compared with the ultrasound group, those in the combination group were significantly higher (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Bushen Huoxue Sanyu decoction combined with high-intensity focusedultrasound can effectively improve clinical symptoms and immune function of patients with adenomyosis, which is safe and effective. |
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