| 郭清保,杨彦龙,史正华,等.重度颅脑外伤病人血清 T细胞激活性低分泌因子、γ-干扰素诱导蛋白 10表达及其预后相关性[J].安徽医药,2023,27(1):140-144. |
| 重度颅脑外伤病人血清 T细胞激活性低分泌因子、γ-干扰素诱导蛋白 10表达及其预后相关性 |
| Expressions of RANTES and IP-10 in serum and prognostic correlation of patients with severe craniocerebral trauma |
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| DOI：10.3969/j.issn.1009-6469.2023.01.031 |
| 中文关键词: 颅脑损伤 T细胞激活性低分泌因子 γ-干扰素诱导蛋白 10 预后 |
| 英文关键词: Craniocerebral trauma Reduced upon activation normal T cell expressed and secreted factor Interferon-γ inducible protein 10 Prognosis |
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| 中文摘要: |
| 目的探究重度颅脑外伤病人血清 T细胞激活性低分泌因子(RANTES)、γ-干扰素诱导蛋白 10(IP-10)水平及其与预后的关系。方法选取 2016年 1月至 2019年 7月中国人民解放军第四军医大学第二附属医院诊治的颅脑外伤病人 174例进行研究，根据格拉斯哥昏迷评分(GCS)将病人分为轻度组(n=58例)中度组(n=58例)、重度组(n=58例)并选取同期体检健康者 58例进行对照研究(健康组)。酶联免疫吸附测定(ELISA)检测血清、RANTES、IP-10水平；Pearson法分析，重度颅脑外伤病人血清 RANTES水平与 IP-10的相关性；比较两组不同预后重度颅脑外伤病人血清 RANTES、IP-10水平；采用受试者操作特征曲(ROC)评价血清 RANTES、IP-10对重度颅脑外伤病人预后的评估价值。结果颅脑外伤病人血清 RANTES［(1.36±0.38)μg/L、(线1.68±0.43)μg/L、(2.06±0.60)μg/L］、IP-10［(247.49±54.45)ng/L、(290.53±62.76)ng/L、(362.18±68.82)ng/L］水平均显著高于健康者(0.88±0.27)μg/L、(194.08±48.33)ng/L(P<0.05)，且血清 RANTES、IP-10水平随疾病程度加重而升高；重度颅脑外伤病人血清 RANTES水平与 IP-10呈正相关(P<0.05)；预后不良亚组重度颅脑外伤病人血清 RANTES(2.45±0.68)μg/L、IP-10(406.32± |
| 英文摘要: |
| Objective To investigate the levels of reduced upon activation normal T cell expressed and secreted factor(RANTES) and interferon-γ inducible protein 10 (IP-10) in patients with severe craniocerebral trauma and their relationship with prognosis.Methods A total of 174 patients with craniocerebral trauma who were treated in The Second Affiliated Hospital the Fourth Military Medical Universit of PLA from January 2016 to July 2019 were selected and assigned into mild group (n = 58 cases), moderate group (n = 58 cases) and severe group (n = 58 cases) according to Glasgow Coma Scale (GCS), and 58 healthy people in the same period were selected for controlstudy (healthy group). The levels of RANTES and IP-10 were detected by enzyme-linked immunosorbent assay (ELISA); Pearson method was used to analyze the correlation between serum RANTES level and IP-10 in patients with severe craniocerebral trauma; the levels of RANTES and IP-10 were compared among patients with severe craniocerebral trauma with different prognosis; in addition, receiver operating characteristic curve (ROC) was used to evaluate the prognostic value of RANTES and IP-10 in patients with severe craniocerebral trauma.Results The levels of RANTES (1.36±0.38) μg/L, (1.68±0.43) μg/L, (2.06±0.60) μg/L and IP-10 (247.49±54.45) ng/L, (290.53±62.76) ng/L, (362.18±68.82) ng/L in patients with craniocerebral trauma were significantly higher than those in healthy subjects (P < 0.05), and the levels of RANTES and IP-10 increased with the severity of the disease; the serum RANTES level was positively correlated with IP-10 in patients with severe craniocerebral trauma (P < 0.05); the serum RANTES (2.45±0.68) μg/L and IP-10 (406.32±72.45) ng/Lin the poor prognosis subgroup were significantly higher than those in the good prognosis subgroup (1.73±0.45) μg/L, (321.29±63.37) ng/L(P < 0.05); the area under the curve (AUC) of serum RANTES and IP-10 levels in predicting the poor prognosis of patients with severe craniocerebral trauma was 0.82 and 0.80 respectively, and the cut-off value was 2.02 μg/L and 355.31 ng/L, respectively, the corresponding sensitivity was 72.0% and 72.0%, and the specificity was 87.9% and 78.8%, respectively; the AUC of the combination of the two methods for predicting poor prognosis of patients with severe craniocerebral trauma was 0.90, and the specificity and sensitivity were 84.8%and 88.0% respectively.Conclusions The levels of serum RANTES and IP-10 in patients with severe craniocerebral trauma are increased. Detection of serum RANTES and IP-10 levels is helpful to evaluate the prognosis of patients. The combination of RANTES and IP-10 can effectively improve the diagnostic efficiency of poor prognosis in patients with severe craniocerebral trauma. |
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