| 史雨璇,殷其改.生后早期血小板参数与早产儿支气管肺发育不良的相关性分析[J].安徽医药,2023,27(2):340-344. |
| 生后早期血小板参数与早产儿支气管肺发育不良的相关性分析 |
| Correlation of early postnatal platelet parameters with bronchopulmonary dysplasia in preterm infants |
| |
| DOI：10.3969/j.issn.1009-6469.2023.02.029 |
| 中文关键词: 支气管肺发育不良 平均血小板体积 血小板参数 血小板 早产儿 |
| 英文关键词: Bronchopulmonary dysplasia Mean platelet volume Platelet parameters Platelets Preterm infants |
| 基金项目: |
|
| 摘要点击次数: 719 |
| 全文下载次数: 233 |
| 中文摘要: |
| 目的探讨生后早期血小板参数与早产儿支气管肺发育不良(BPD)的相关性。方法采用回顾性病例对照研究，收集 2013年 1月至 2020年 12月徐州医科大学附属连云港医院新生儿重症监护病房收治的胎龄 ≤32周的早产儿的临床一般资料和生后 2h、生后 24~48 h的血小板参数:血小板计数( PLT)、平均血小板体积( MPV)、血小板压积( PCT)、血小板分布宽度( PDW)，根据早产儿是否患有 BPD分为 BPD与非 BPD组，比较两组的一般资料、围产资料、临床特征及血小板参数。采用二元 logistic回归分析 BPD发生的危险因素，受试者操作特征曲线( ROC曲线)分析血小板参数对 BPD的预测价值。结果两组间生后 2h内 PLT、MPV、PCT、PDW比较差异无统计学意义。 BPD组生后 24~48 h内 MPV水平高于非 BPD组［( 10.18±0.80)fL比( 9.43±0.63) fL］差异有统计学意义；两组间 PLT、PCT、PDW差异无统计学意义。多因素 logistic回归分析显示出生胎龄小［OR=0.24，95%CI:(0.07］CPAP时间长［OR=1.42，(1.08，、［OR=1.57，(1.11， ］0.87)、 95%CI:1.87)机械通气时间长95%CI:2.21)输注红细胞次数多［OR=2.28，95%CI:4.86)、［OR95%CI:123.90)是发生 BPD的独立危险因素。当生(1.07， ］生后 24~48 h内 MPV大=17.80，(2.56，］后 24~48 h内 MPV的诊断界值为 9.6时，预测 BPD的灵敏度为 77.1%，特异度为 64.9%。结论生后 24~48 h内较高水平的 MPV是发生 BPD的独立危险因素。生后 24~48 h MPV>9.6fL可作为 ≤32周早产儿 BPD发生的较敏感的预测指标。 |
| 英文摘要: |
| Objective To investigate the correlation between early postnatal platelet parameters and bronchopulmonary dysplasia (BPD) in preterm infants.Methods A retrospective case.control study was conducted to collect general clinical data and platelet pa-rameters, including platelet count (PLT), mean platelet volume (MPV), platelet accumulation (PCT), and platelet distribution width(PDW), from 2 h after birth and 24 to 48 h after birth of premature infants with gestational age ≤ 32 weeks who were admitted to theNeonatal Intensive Care Unit of Lianyungang Hospital Affiliated to Xuzhou Medical University from January 1, 2013, to December 30,2020. Preterm infants were divided into BPD and non-BPD groups according to whether they had BPD, and the general data, perinataldata, clinical characteristics and platelet parameters of the two groups were compared. Binary logistic regression was used to analyzethe risk factors for the occurrence of BPD, and subject operating characteristic curves (ROC curves) were used to analyze the predictivevalue of platelet parameters for BPD.Results The differences in PLT, MPV, PCT, and PDW within 2 h after birth were not statisticallysignificant between the two groups. The level of MPV within 24-48 h after birth in the BPD group was higher than that in the non-BPD group [(10.18±0.80) fL vs. (9.43±0.63) fL], and the differences were statistically significant; the differences in PLT, PCT and PDW be-tween the two groups were not statistically significant.Multivariate logistic regression analysis showed that small birth gestational age[OR=0.24,95%CI:(0.07,0.87)], long duration of CPAP [OR=1.42,95%CI:(1.08,1.87)],long duration of mechanical ventilation [OR=1.57, 95%CI:(1.11, 2.21)], and high frequency of erythrocyte infusions [OR=2.28,95%CI:(1.07,4.86)],and large MPV within 24-48 h [OR= 17.80,95%CI:(2.56,123.90)] were independent risk factors for the development of BPD. When the diagnostic cutoff value of MPV within 24-48 h postnatally was 9.6, the sensitivity of predicting BPD was 77.1%,and the specificity was 64.9%.Conclusions High levels of MPV within 24-48 h postnatally are an independent risk factor for for the development of BPD.MPV>9.6 fL within 24-48 h postnatally can be a more sensitive predictor for the development of BPD in preterm infants ≤32 weeks. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
