| 张洁,陈雪妍,姚美丹,等.中医药治疗糖尿病便秘用药规律探讨[J].安徽医药,2023,27(2):404-408. |
| 中医药治疗糖尿病便秘用药规律探讨 |
| Discussion on the rules of Chinese medicine for diabetic constipation |
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| DOI：10.3969/j.issn.1009-6469.2023.02.045 |
| 中文关键词: 糖尿病并发症 便秘 中草药 数据挖掘 用药规律 |
| 英文关键词: Diabetes complications Constipation Drugs, Chinese herbal Data mining Medication rule |
| 基金项目: |
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| 摘要点击次数: 1489 |
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| 中文摘要: |
| 目的探求治疗糖尿病便秘的中药组方规律。方法自 2021年 1―7月从 CNKI、CBM、VIP、WANFANG中筛选关于应用中药治疗糖尿病便秘的临床试验文献 110篇，搜集组方用药后运用频数统计、关联规则、聚类和因子分析方法，探讨其中的用药配伍规律。结果最终纳入 104首中药复方，涉及 125味中药，结果显示用药频次 ≥10的有 27味中药，药物功效以补益为主，性味多甘温，主要归脾、胃、肺三经，关联规则分析得到 15条；聚类分析结果选取出 8组具有关联性的药组；通过因子分析方法，得到公因子 11个。结论中医药治疗糖尿病便秘以养阴生津为主，同时结合消渴病的病机特点，灵活运用温阳、活血、理气类药物。 |
| 英文摘要: |
| Objective To explore the rule of Chinese medicine formulae for diabetic constipation therapy.Methods From Januaryto July 2021, 110 clinical trials on the application of Chinese herbal medicines for diabetic constipation were screened from CNKI,CBM, VIP, and WANFANG, and the frequency statistics, association rules, clustering, and factor analysis methods were used after col-lecting the grouped prescriptions to explore the drug combination rules among them.Results A total of 104 Chinese medicine com-pounds involving 125 Chinese medicines were finally included, and the results showed that there were 27 Chinese medicines with a fre-quency of ≥ 10. The efficacy of the medicines was mainly tonic, sweet and warm in nature, and mainly belonged to the spleen, stomachand lung meridians. Fifteen association rules were obtained from the analysis of association rules. Eight groups of medicine groups withassociations were selected from the results of cluster analysis. Eleven common factors were obtained by the factor analysis method.Con. clusion Diabetic constipation is treated by Chinese medicine mainly by nourishing yin and promoting fluid, while combining the path-ological characteristics of achalasia with the flexible use of warming Yang, invigorating blood and regulating qi drugs. |
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