| 惠琼琼,师丛,叶新华.胰岛素样生长因子-1 与儿童肥胖的相关性研究进展[J].安徽医药,2023,27(3):428-432. |
| 胰岛素样生长因子-1 与儿童肥胖的相关性研究进展 |
| Research progress on the correlation between IGF-1 and childhood obesity |
| |
| DOI：10.3969/j.issn.1009-6469.2023.03.002 |
| 中文关键词: 肥胖 胰岛素样生长因子-1 儿童 综述 |
| 英文关键词: Obesity Insulin-like growth factor-1 Children Review |
| 基金项目:甘肃省自然科学基金(20JR10RA695)；甘肃省卫生行业计划项目(ldyyyn2018-77) |
|
| 摘要点击次数: 1426 |
| 全文下载次数: 651 |
| 中文摘要: |
| 21世纪，儿童肥胖的发生率居高不下。它对健康的影响及医疗资源造成的负担令人担忧，已成为了世界性的公共卫生问题。研究显示，在儿童肥胖发生发展中，胰岛素样生长因子-1(IGF-1)是关键因素之一。IGF-1对肥胖的影响主要是由于其在机体内参与的一些反应的平衡状态被打破，比如营养元素代谢、炎症反应、肠道菌群平衡及激素和生长因子的合成、分泌等，从而诱导儿童肥胖；同时上述机制改变也可能会引起或加速与肥胖相关的性早熟、阻塞性睡眠呼吸暂停、哮喘、非酒精性脂肪肝、心血管、社会心理行为等多系统并发症的发生，需引起临床医师的警惕。该综述总结了IGF-1在儿童肥胖及其并发症中的研究进展。 |
| 英文摘要: |
| In the 21st century, the incidence of childhood obesity remains high. Its impact on health and burden of medical resources is worrying and it has become a worldwide public health problem. Studies have shown that insulin-like growth factor-1 (IGF-1) is one of the key factors in the occurrence and development of childhood obesity. The effect of IGF-1 on obesity is mainly due to the disruption of the balance state of some reactions involved in IGF-1, such as nutrient metabolism, inflammation, intestinal flora balance, and the syn-thesis and secretion of hormones and growth factors, thus inducing obesity in children. Meanwhile, the above-mentioned mechanism changes may also cause or accelerate the occurrence of obesity-related complications such as precocious puberty, obstructive sleep ap-nea, asthma, non-alcoholic fatty liver disease, cardiovascular disease and psychosocial behavior, which should arouse the vigilance of clinicians. This study summarized the research progress of IGF-1 in childhood obesity and its complications. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
