| 檀飞飞,周中银.粪便钙卫蛋白与溃疡性结肠炎活动相关性初步研究[J].安徽医药,2023,27(3):568-571. |
| 粪便钙卫蛋白与溃疡性结肠炎活动相关性初步研究 |
| A preliminary study on the correlation between fecal calprotectin and ulcerative colitis |
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| DOI：10.3969/j.issn.1009-6469.2023.03.032 |
| 中文关键词: 结肠炎，溃疡性 粪便钙卫蛋白 活动性 |
| 英文关键词: Colitis, ulcerative Fecal calprotectin Activity |
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| 中文摘要: |
| 目的 评估粪便钙卫蛋白(FC)作为溃疡性结肠炎( UC) 疾病活动性的非侵入性标志物的作用。方法 选取2020年1月至2021年10月在武汉大学人民医院消化内科住院治疗的UC病人66例，收集他们的基本信息及临床资料，按照改良Mayo评分及Truelove分期分别对病人进行分组，比较同一分组的不同组别间FC、C反应蛋白(CRP)、红细胞沉降率(ESR)、血小板及白细胞值是否有差异，并将FC与CRP、ESR、血小板、白细胞、病变范围及取样大便的特征进行相关性分析，探讨FC可能的影响因素。结果 Mayo分组中，轻、中、重度活动期组FC 值分别为79.30(21.85，195.44)μg/g、 43.00(15.00， 122.45)μg/g、34.50(21.95， 53.55)μg/g，P=0.400；Truelove组中，轻、中、重度组FC 值分别为90.50(45.85， 211.50)μg/g、 52.50(24.00， 188.80)μg/g、35.80(22.80， 55.25)μg/g，P=0.410，不同组别间FC值均差异无统计学意义。Spearman相关性分析显示FC与CRP、ESR、血小板、白细胞及取样大便的颜色、性状、红细胞数、白细胞数等均无统计学关系，与病变范围也无统计学关系(均P>0.05)。结论FC不能用于区别处于不同活动期的UC病人；可能的原因为FC昼夜差距大及采集和检验装置的失误，建议改进目前的采集装置及检测方法，并统一检测病人清晨的大便标本。 |
| 英文摘要: |
| Objective To evaluate the role of fecal calprotectin (FC) as a noninvasive marker of disease activity in ulcerative Coloni?tis (UC).Methods A total of 66 UC patients hospitalized in the Department of Gastroenterology, Renmin Hospital of Wuhan Universi?ty from January 2020 to October 2021 were selected. Their basic information and clinical data were collected, and the patients were as?signed into different groups according to modified Mayo Scores and Truelove stages. the differences of FC, C-reactive protein (CRP),Erythrocyte sedimentation rate (ESR), Platelet and white blood cell among different groups in the same group were compared, and the correlation between FC and ESR, CRP, Platelet,white blood cell, lesion range and the nature of sampled stool was analyzed to explore the possible influencing factors of FC.Results The FC values of the Mayo group were 79.30 (21.85, 195.44) μg/g, 43.00 (15.00,122.45) μg/g and 34.50 (21.95, 53.55) μg/g, respectively (P=0.400). In the Truelove group, FC of the mild, moderate and severe groups were 90.50 (45.85, 211.50) μg/g, 52.50 (24.00, 188.80) μg/g and 35.80 (22.80, 55.25) μg/g, respectively (P=0.410). There was no sig?nificant difference in FC values between different groups. Spearman correlation analysis showed that FC had no statistical relationship with ESR, CRP, Platelet, white blood cell, color, character, red blood cell number, white blood cell number, and lesion range (all P>0.05).Conclusions FC cannot be used to distinguish UC patients in different active stages in this hospital, so it is not recommended that doctors in this hospital judge patients' activity based on FC values. Considering that the possible reasons are the large gap between day and night of FC, and the error of collection and inspection devices, it is suggested to improve the current collection devices and de?tection methods, and uniformly detect patients' stool specimens in the morning. |
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