| 赖泉龙,李奕鑫,黄国亮,等.中药“717 解毒合剂”治疗蝮蛇咬伤病人的临床效果研究[J].安徽医药,2023,27(3):611-615. |
| 中药“717 解毒合剂”治疗蝮蛇咬伤病人的临床效果研究 |
| Clinical effects of Chinese medicine 717 Jiedu Mixture in treating patients with agkistrodon halys bite |
| |
| DOI：10.3969/j.issn.1009-6469.2023.03.042 |
| 中文关键词: 蛇咬伤 蝮蛇属 中草药 717解毒合剂 临床效果 心肌 肾损伤 |
| 英文关键词: Snake Bites Agkistrodon Drugs, Chinese herbal 717 Jiedu Mixture Clinical effect Myocardium Kidney injury |
| 基金项目:广西壮族自治区卫生健康委青年基金(Z20200021) |
|
| 摘要点击次数: 640 |
| 全文下载次数: 205 |
| 中文摘要: |
| 目的 探究自拟中药方717解毒合剂治疗蝮蛇咬伤病人的临床效果。方法 选取2018年9月至2021年6月中国人民解放军联勤保障部队第九一〇医院收治的68例被蝮蛇咬伤的病人，根据随机数字表法分为观察组和对照组。其中对照组采用常规西药治疗(抗蝮蛇毒血清6 000 U加入0.9%氯化钠注射液250 mL静脉滴注)，观察组在常规西药治疗的基础上加服自拟中药方717解毒合剂，每组34例。比较两组病人的临床疗效。结果 观察组病人治愈人数23例(占比67.65%)，总有效率为91.18%；对照组治愈人数16例(占比47.06%)，总有效率为82.35%；观察组治愈人数显著多于对照组(P<0.05)；经治疗后，观察组病人急性生理学和慢性健康状况评价Ⅱ(APACHE Ⅱ)评分明显优于对照组(P<0.05)。治疗前，两组病人血清乳酸脱氢酶(LDH)、肌酸激酶及肌酸激酶同工酶(CK-MB)的含量相比较差异无统计学意义(P>0.05)；经治疗后，随着治疗天数的增加，各指标出现明显好转，并且观察组改善效果显著优于对照组(P<0.05)。治疗前，两组病人肾损伤相关因子血清肌酐、血浆中中性粒细胞明胶酶相关脂质运载蛋白(pNGAL)、尿液中中性粒细胞明胶酶相关脂质运载蛋白(uNGAL)含量相比较差异无统计学意义(P>0.05)；经治疗后，随着治疗天数的增加，各指标出现明显好转，并且观察组改善效果显著优于对照组(P<0.05)。结论 717解毒合剂联合西医治疗蝮蛇咬伤后病人的临床治疗效果相比于单独采用西医治疗更显著，能够快速降低病人血清内的毒素，减少毒素对于心肌细胞的损伤以及肾损伤，值得临床推广。 |
| 英文摘要: |
| Objective To explore the clinical effect of self-made traditional Chinese medicine prescription 717 Jiedu Mixture in treating patients after agkistrodon halys bite.Methods Totally 68 patients bitten by Agkistrodon halys, who were admitted to The 910 Hospital of Joint Logistics Support Force of the People's Liberation Army of China from September 2018 to June 2021, were selected and assigned into observation group (n=34) and control group (n=34) according to random number table. Among them, the control group was treated with conventional Western medicine (6 000 U of anti-agkistrodon halys venom serum and 250 mL of 0.9% sodium chloride injection were injected intravenously), and the observation group was treated with self-made traditional Chinese medicine prescription 717 Jiedu Mixture on the basis of conventional Western medicine. The clinical effects of the two groups were compared.Results In the observation group, 23 (67.65%) patients were cured, and the total effective rate was 91.18%. In the control group, 16 (47.06%) cas?es were cured, and the total effective rate was 82.35%. The number of cured patients in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the score of acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) in the observation group was significantly higher than that in the control group (P<0.05). Before treatment, there was no significant dif?ference in the levels of serum lactate dehydrogenase (LDH), creatine kinase and creatine kinase myocardial band (CK-MB) between the two groups (P>0.05). After treatment, with the increase of treatment days, all indicators improved significantly, and the improvement ef?fect of the observation group was significantly better than that of the control group (P<0.05). Before treatment, there was no statistically significant difference between the two groups in the levels of serum creatinine, plasma neutrophil gelatinase-associated lipocalin (pN?GAL) and urinary neutrophil gelatinase-associated lipocalin (uNGAL). After treatment, with the increase of treatment days, all indica?tors improved significantly, and the improvement effect of the observation group was significantly better than that of the control group (P<0.05).Conclusions During the same treatment time period, the clinical treatment effect of 717 Jiedu Mixture combined with Western medicine in treating patients with Agkistrodon halys bite is better than that of patients treated with Western medicine alone. It can rap?idly reduce the toxin in the patient's serum, and reduce the damage of the toxin to myocardial cells and kidney, which is worth clinical promotion. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
