| 吴瑞民,史慧芳.个体化营养干预联合益气养阴方对妊娠糖尿病病人血糖、血脂、胰岛 β细胞功能指标的影响[J].安徽医药,2023,27(4):750-753. |
| 个体化营养干预联合益气养阴方对妊娠糖尿病病人血糖、血脂、胰岛 β细胞功能指标的影响 |
| Effects of individualized nutritional intervention combined with Yiqi Yangyin formula on blood glucose, blood lipids and pancreatic β-cell function indexes in patients with gestational diabetes mellitus |
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| DOI：10.3969/j.issn.1009-6469.2023.04.026 |
| 中文关键词: 糖尿病，妊娠 精准医学 个体化营养干预 益气养阴方 糖脂代谢 胰岛 β细胞 血糖波动 胰岛素抵抗 |
| 英文关键词: Diabetes, gestational Precision medicine Individualized nutrition intervention Yiqi Yangyin formula Glucose and lipid metabolism Pancreatic β-cell Blood glucose fluctuation Insulin resistance |
| 基金项目:河北省中医药管理局 2020年度中医药类科研计划项目( 2020558) |
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| 中文摘要: |
| 目的探讨个体化营养干预联合益气养阴方对妊娠糖尿病( GDM)病人血糖波动、血脂指标、胰岛 β细胞功能的影响。方法选择 2018年 1月至 2019年 12月邢台医学高等专科学校第二附属医院收治的 120例 GDM病人，采用随机数字表法将病人分为两组。对照组( 60例)采用西医常规治疗联合益气养阴方治疗，观察组( 60例)在对照组基础上增加个体化营养干预。观察两组治疗前后血糖波动、血脂指标和胰岛 β细胞功能差异。结果两组治疗后日内平均血糖波动幅度( MAGE)、血糖水平标准差( SDBG)、平均餐后血糖波动幅度( MPPGE)、日间血糖波动幅度( MODD)、血清总胆固醇( TC)、载脂蛋白 B(ApoB)、胰岛素抵抗指标［HOMA-IR(C-P)］均下降(P<0.05)载脂蛋白 A1(ApoA1)ApoA1/ApoB比值、精氨酸刺激 3 min C肽( C-P)、C-P峰值/空腹 C肽( FC-P)、胰岛β细胞功能指数［HOMA-β，(C-P)］升高(P<0.05)。、观察组治疗后 MAGE［( 3.62±0.51)mmol/L比( 4.25±0.69)mmol/L］、 SDBG［( 1.91±0.16)mmol/L比( 2.12±0.21)mmol/L］、 MPPGE、MODD、血清 TC、ApoB、HOMA-IR(C-P)低于对照组(P<0.05)ApoA1［( 1.43±0.65)g/L比( 1.12±0.36)g/L］、 ApoA1/ApoB比值［( 1.47±0.26)比( 0.97±0.20)］、精氨酸刺激 3 min C-P［( 6.97±1.06，)μg/L比( 5.09±0.76)μg/L］、 C-P峰值 /FC-P［( 2.91±0.85)比( 1.91±0.72)］、 HOMA-β(C-P)［( 2.16±0.77)比( 1.92±0.62)］高于对照组( P<0.05)。结论个体化营养干预联合益气养阴方更有助于维持妊娠期间血糖稳定，降低血脂水平，改善胰岛 β细胞储备功能，降低胰岛素抵抗。 |
| 英文摘要: |
| Objective To investigate the effects of individualized nutritional intervention combined with Yiqi Yangyin formula on blood glucose fluctuation, blood lipid index and pancreatic β-cell function in patients with gestational diabetes mellitus (GDM).Meth? ods A total of 120 patients with GDM admitted to the Second Affiliated Hospital of Xingtai Medical College from January 2018 to December 2019 were selected and divided into two groups by the random number table method. The control group (60 cases) was treatedwith conventional Western medicine treatment combined with Yiqi Yangyin formula, while the observation group (60 cases) was treatedwith additional individualized nutritional interventions on the basis of the control group. Differences in blood glucose fluctuation, bloodlipid index and pancreatic β-cell function between the two groups before and after treatment were observed.Results Mean postprandial glucose excursions (MAGE), standard deviation blood glucose (SDBG), mean postprandial glucose excursion (MPPGE), means of daily differences (MODD), total cholesterol (TC), apolipoprotein B (ApoB), and HOMA-IR (C-P) were all decreased (P < 0.05), and apolipoprotein A1 (ApoA1), ApoA1/ApoB ratio, arginine-stimulated 3 min c-peptide (C-P), peak C-P/fasting C-peptide (FC-P), and islet β-cell function index [HOMA-β (C-P)] were increased (P < 0.05). In the observation group, after treatment, MAGE [(3.62±0.51) mmol/L vs. (4.25±0.69) mmol/L], SDBG [(1.91±0.16) mmol/L vs. (2.12±0.21) mmol/L], MPPGE, MODD, serum TC , ApoB, HOMA-IR (C-P) were lower than those of the control group (P < 0.05), and ApoA1 [(1.43±0.65) g/L vs. (1.12±0.36) g/L], ApoA1/ApoB ratio [(1.47±0.26) vs. (0.97±0.20)], arginine-stimulated 3 min C-P [(6.97±1.06) μg/L vs. (5.09±0.76) μg/L], peak C-P/FC-P [(2.91±0.85) vs. (1.91±0.72)], and HOMA-β (C-P) [(2.16±0.77) vs. (1.92±0.62)] were higher than those of the control group (P < 0.05).Conclusion The combination of individualized nutritional interventions with Yiqi Yangyin formula is more helpful in maintaining stable glucose, lowering blood lipid levels, improving pancreatic β-cell reserve function, and reducing insulin resistance during pregnancy. |
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