| 朱来运,刘静,黄小雨,等.纤维蛋白原与吉兰 -巴雷综合征病情严重程度的相关性研究[J].安徽医药,2023,27(4):804-808. |
| 纤维蛋白原与吉兰 -巴雷综合征病情严重程度的相关性研究 |
| Correlation of fibrinogen and disease severity of Gilland-Barre syndrome. |
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| DOI：10.3969/j.issn.1009-6469.2023.04.039 |
| 中文关键词: 吉兰 -巴雷综合征 纤维蛋白原 白蛋白 危险因素 |
| 英文关键词: Guillain-Barré syndrome Fibrinogen Albumin Risk factors |
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| 中文摘要: |
| 目的探讨纤维蛋白原( FIB)与吉兰 -巴雷综合征( Guillain-Barre syndrome，GBS)病人的病情严重程度之间的关系及 FIB能否成为预测重型 GBS的可靠指标。方法纳入 2018年 10月至 2021年 10月于徐州医科大学附属医院收治的 81例确诊 GBS病人，收集病人的一般临床资料，血清白蛋白、血清球蛋白、纤维蛋白原、白细胞计数、脑脊液蛋白及肌电图检查结果。根据病人病情高峰时的 Hughes评分将其分为轻型 GBS(26例)(<3分)，重型 GBS(55例)(≥3分)；根据肌电图将 GBS病人分为急性炎症性脱髓鞘性多发性神经根神经病(AIDP)、急性运动轴索性神经病(AMAN)、急性运动感觉轴索性神经病( AMSAM)。比较轻型、重型 GBS的临床指标；比较 FIB与不同分型之间的关系；进一步行影响 GBS病人病情严重程度的多因素回归分析，并且采用受试者操作特征曲线( ROC曲线)评价 FIB对重型 GBS病人的预测价值。结果轻型 GBS病人的年龄、肢体无力所占比例、 FIB 2.53(2.28，3.18)g/L、血清白蛋白( 45.87±4.46)g/L、血清球蛋白、白细胞与重型 GBS病人 FIB 3.29(2.61，4.33)g/L、血清白蛋白( 41.56±4.95)g/L均差异有统计学意义( P<0.05)。多因素 logistic回归分析，结果提示 FIB为重型 GBS的独立危险因素( P<0.05)。以 FIB值为自变量， ROC分析 FIB值预测重型 GBS病人的曲线下面积( AUC)为 0.74，当 FIB以 2.82 g/L为界值时对重型 GBS的预测效果最佳。结论 FIB水平与 GBS病情严重程度相关，并且是重型 GBS的独立危险因素， FIB对重型 GBS的发生具有一定的预测价值。 |
| 英文摘要: |
| Objective To investigate the relationship between fibrinogen (FIB) and the severity of Guillain Barre syndrome (GBS),and whether FIB can be a reliable index for predicting severe GBS.Methods Eighty-one patients with GBS admitted to the AffiliatedHospital of Xuzhou Medical University from October to October 2021 were included. The general clinical data, serum albumin, serumglobulin, fibrinogen, leukocyte count, cerebrospinal fluid protein and electromyography were collected. The patients were divided intomild GBS (26 cases) (< 3 points) and severe GBS (55 cases) (≥3 points) according to the Hughes score at the peak of the disease; Patients with GBS were divided into acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN)and acute motor sensory axonal neuropathy (AMSAM) according to electromyography. The clinical indexes of mild and severe GBS werecompared; the relationship between FIB and different typing was also compared; Further multivariate regression analysis was conductedto evaluate the predictive value of FIB for patients with severe GBS, and receiver operating characteristic curve (ROC) was used to evaluate the predictive value of FIB for patients with severe GBS.Results There were differences in age, proportion of limb weakness, FIB 2.53 (2.28, 3.18) g/L, serum albumin (45.87±4.46) g/L, serum glo ulin, leukocyte between patients with mild GBS and patients with severe GBS FIB 3.29 (2.61, 4.33) g/L, serum albumin (41.56 ± 4.95) g/L (P<0.05). Multivariate logistic regression analysis showed that FIB was an independent risk factor for severe GBS (P<0.05). Taking FIB value as independent variable, ROC analysis FIB value predicted the area under the curve (AUC) of patients with severe GBS was 0.742. When FIB was 2.82 g/L as the boundary value, the prediction effect of severe GBS was the best.Conclusion FIB level is related to the severity of GBS and is an independent risk factor forsevere GBS. FIB has a certain predictive value for the occurrence of severe GBS. |
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