| 冀召帅,高远,赵莹鹏,等.碳青霉烯耐药 G-杆菌分布特征及其与抗菌药物使用强度相关性分析[J].安徽医药,2023,27(4):844-848. |
| 碳青霉烯耐药 G-杆菌分布特征及其与抗菌药物使用强度相关性分析 |
| Distribution characteristics of carbapenem-resistant organisms and its correlation with the intensity of antibiotic use |
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| DOI：10.3969/j.issn.1009-6469.2023.04.049 |
| 中文关键词: 革兰阴性杆菌 抗药性，多种，细菌 碳青霉烯类 抗菌药物使用强度 相关性分析 |
| 英文关键词: Gram negative bacillus Drug resistance, multiple, bacterial Carbapenems Antibiotics use density Correlation analysis |
| 基金项目:北京市医院管理中心创新梦工场经费资助( 202121) |
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| 中文摘要: |
| 目的探讨碳青霉烯耐药革兰阴性杆菌( CRO)耐药特征以及与碳青霉烯类抗菌药物使用强度( AUD)之间的相关性。方法统计北京清华长庚医院 2016—2020年分离的 CRO临床资料以及同期碳青霉烯类药物使用情况，分析两者之间的相关性。结果临床共分离出 CRO菌株 3 342株，其中以碳青霉烯耐药肺炎克雷伯菌( CRKP)1 280株( 38.30%)、碳青霉烯耐药鲍曼不动杆菌( CRAB)1 094株( 32.73%)、碳青霉烯耐药铜绿假单胞菌( CRPA)609株( 18.22%)、碳青霉烯耐药大肠埃希菌(CREC)136株( 4.07%)为主；分布科室主要有重症医学科 1 423株( 42.58%)、普内科 406(12.15%)、肝胆胰外科 310(9.28%)等； 2016—2020年 CRO、CRKP、碳青霉烯耐药阴沟肠杆菌检出率均呈逐年上升趋势，其检出率与美罗培南使用强度呈强相关( r= |
| 英文摘要: |
| Objective To investigate the distribution characteristics of Carbapenem-Resistant Organisms (CRO), and the correlation between CRO and the Antibiotics Use Density of carbapenem (AUD).Methods The clinical data of CRO and the use of carbapenemsin Beijing Tsinghua Changgung Hospital from 2016 to 2020 were retrospectively collected, then the correlation was statistically analyzed. Results A total of 3342 CRO strains were detected, including 1280 strains of carbapenem resistant Klebsiella Pneumoniae(CRKP) (38.30%), 1094 strains of carbapenem resistant Acinetobacter baumannii (CRAB) (32.73%), 609 strains of carbapenem resistant Pseudomonas Aeruginosa (CRPA) (18.22%) and 136 strains of carbapenem resistant Escherichia Coli (CREC) (4.07%). As for thedepartment distribution, there were 1 423 strains (42.58%) in intensive care, 406 (12.15%) in general medicine and 310 (9.28%) inhepatobiliary and pancreatic surgery.. From 2016 to 2020, the detection rates of CRO, CRKP and carbapenem resistant Enterobacter cloacae showed an upward trend year by year, and the detection rates were strongly correlated with the use intensity of meropenem (r = 0.90, 0.90 and 1.00, respectively), while the detection rates of CRAB and CRPA were moderately correlated with meropenem (r = 0.50 and 0.70, respectively); the detection rate of CREC was moderately correlated with imipenem (r = 0.50).Conclusions The drug resistance rate of CRO, especially CRKP and carbapenem resistant Enterobacter cloacae, are still rising, and are strongly correlated with theuse intensity of meropenem. The clinical application management of antibiotics should be strengthened to curb the growth of CRO. |
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