| 王歆,刘维英.固醇调节元件结合蛋白 -1与阻塞性睡眠呼吸暂停代谢异常的研究进展[J].安徽医药,2023,27(5):854-858. |
| 固醇调节元件结合蛋白 -1与阻塞性睡眠呼吸暂停代谢异常的研究进展 |
| Research progress of sterol regulatory element binding protein-1 and obstructive sleep apnea metabolic abnormality |
| |
| DOI：10.3969/j.issn.1009-6469.2023.05.002 |
| 中文关键词: 睡眠呼吸暂停，阻塞性 间歇性缺氧 固醇调节元件结合蛋白 -1 高脂血症 胰岛素抵抗 动脉粥样硬化 非酒精性脂肪性肝病 |
| 英文关键词: Sleep apnea, obstructive Intermittent hypoxia sis Non-alcoholic fatty liver disease |
| 基金项目:甘肃省自然科学基金资助项目( 21JR1RA074) |
|
| 摘要点击次数: 929 |
| 全文下载次数: 335 |
| 中文摘要: |
| 阻塞性睡眠呼吸暂停( OSA)是高脂血症、胰岛素抵抗、动脉粥样硬化、非酒精性脂肪性肝病的危险因素，其病理基础的核心是间歇性低氧( IH)。固醇调节元件结合蛋白( SREBP)是脂质生物合成的一类调控因子，主要在肝脏和脂肪细胞中表达，参与调节脂肪酸和胆固醇生物合成。近年来， SREBP-1在 IH条件下表达上调对脂质合成的影响备受关注。现针对 SREBP-1在 IH下对 OSA相关代谢性疾病的研究进展进行综述，为预防或延缓 OSA相关代谢疾病的进展以及新的靶向治疗提供思路。 |
| 英文摘要: |
| Obstructive sleep apnea (OSA) is a risk factor for hyperlipidemia, insulin resistance, atherosclerosis, and non-alcoholic fat-ty liver disease, and the core of its pathological basis is intermittent hypoxia (IH). Sterol regulatory element binding protein (SREBP) isa kind of regulatory factor of lipid biosynthesis, which is mainly expressed in liver and adipose cells and participates in regulating fattyacid and cholesterol biosynthesis. In recent years, the effects of increased expression of SREBP-1 on lipid synthesis under IH condi-tions have attracted much attention. This paper reviews the research progress of the impact of SREBP-1 on OSA-related metabolic dis-eases under IH, providing ideas for prevention or delay of OSA-related metabolic diseases and new targeted therapies. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
