| 张海姣,兰丽珍.甲状腺癌分子标志物的研究进展[J].安徽医药,2023,27(5):875-879. |
| 甲状腺癌分子标志物的研究进展 |
| Advances in molecular markers of thyroid cancer |
| |
| DOI：10.3969/j.issn.1009-6469.2023.05.006 |
| 中文关键词: 甲状腺结节 甲状腺癌 分子标志物 |
| 英文关键词: Thyroid nodule Thyroid cancer Molecular markers |
| 基金项目: |
|
| 摘要点击次数: 955 |
| 全文下载次数: 299 |
| 中文摘要: |
| 超声波检查的应用和进步使甲状腺结节的检出率越来越高，区分甲状腺良恶性结节的主要方法除了超声波检查的临床分级外，目前只有甲状腺细针穿刺活检( FNAB)，穿刺病理学上， 20%~25%的结节其良恶性是不确定的。肿瘤的发生是单一变异细胞多次克隆的结果，涉及多步骤、多基因的癌变。同样，大部分甲状腺癌也存在一种或几种基因异常，这些基因异常可作为潜在的标志物应用于甲状腺癌的诊断、预测预后以及治疗靶点，对临床具有重要意义。 |
| 英文摘要: |
| The application and progress of ultrasonic examination make the detection rate of thyroid nodules higher and higher. Be-sides the clinical classification of ultrasonic examination, the main method to distinguish benign and malignant nodules is fine needlebiopsy aspiration (FNAB) of thyroid, pathologically, 20%-25% of nodules are undetermined in their malignancy. The occurrence of tu-mor is the result of multiple cloning of a single mutant cell, involving multi-step, multi-gene carcinogenesis. Most thyroid cancers alsohave one or several genetic abnormalities. These genetic abnormalities can be used as potential markers for diagnosis, prognosis andtherapeutic targets of thyroid cancer, which is of great clinical significance. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
