| 陆通,刘浩楠,吴克俭.晚期肺癌炎症指数与胃癌病理特征的相关性分析[J].安徽医药,2023,27(5):928-931. |
| 晚期肺癌炎症指数与胃癌病理特征的相关性分析 |
| Correlation analysis of inflammatory index of advanced lung cancer and pathological characteristics of gastric cancer |
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| DOI：10.3969/j.issn.1009-6469.2023.05.017 |
| 中文关键词: 胃肿瘤 晚期肺癌炎症指数 TNM分期 早期预测 |
| 英文关键词: Stomach neoplasms The advanced lung cancer inflammation index Tumor TNM staging Early prediction |
| 基金项目:江苏省卫生健康委员会科研项目( LGY2020006) |
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| 中文摘要: |
| 目的探讨晚期肺癌炎症指数( ALI)与胃癌病理特征的相关性。方法 2018年 9月至 2020年 5月在徐州医科大学附属医院普外科行胃癌根治术的胃癌病人 280例作为胃癌组，其中再按 ALI水平分为 ALI降低组及 ALI升高组。以徐州医科大学附属医院体检中心的 100名健康人群为对照组，比较胃癌组与对照组 ALI、ALI降低组与 ALI升高组肿瘤浸润程度、淋巴结转移情况和 TNM分期，分析这些指标与 ALI之间的相关性。结果胃癌组 ALI水平明显低于对照组［ 39.17(25.98，59.93)比 66.06(51.99，82.98)，P<0.05］； ALI降低组与 ALI升高组比较，肿瘤最大径更大［ 108(74.5%)例比 37(25.5%)例］、浸润更深、淋巴结转移数目更多［ 128(74.4%)例比 44(25.6%)例］、 TNM分期更晚( P<0.05)；但在肿瘤分化程度上差异无统计学意义( P>0.05)。胃癌组 ALI升高预示肿瘤处于 I期，浸润深度为 T1的可能性大，即胃癌病人 ALI升高表明肿瘤处于早期。结论在胃癌病人中， ALI数值越低，提示肿瘤浸润越深、淋巴结转移越多、肿瘤长径越大及 TNM分期越晚，预后越差。 |
| 英文摘要: |
| Objective To explore the correlation between the advanced lung cancer inflammation index (ALI) and the pathological features of gastric cancer.Methods Two hundred and eighty patients with gastric cancer who underwent radical gastrectomy in gener-al surgery of the Affiliated Hospital of Xuzhou Medical University from September 2018 to May 2020 were taken as gastric cancergroup, and 100 healthy people in physical examination center of the Affiliated Hospital of Xuzhou Medical University were taken ascontrol group. The differences of ALI (ALI=BMI×ALB / NLR) between gastric cancer group and healthy people group, as well as the de-gree of tumor invasion, lymph node metastasis and TNM stage were compared, and the correlation between these indexes and ALI wasanalyzed.Results Compared with the control group, the gastric cancer group decreased significantly [39.17 (25.98, 59.93) vs. 66.06 (51.99, 82.98), P<0.05]. Compared with patients with elevated ALI, patients with reduced ALI had larger tumor diameter [108 (74.5%) vs. 37 (25.5%)], deeper invasion, more lymph node metastasis [128 (74.4%) vs. 44 (25.6%)] and later TNM stage (P<0.05). But there was no significant difference in the degree of tumor differentiation (P>0.05). The increase of ALI in gastric cancer group indicated thatthe tumor was in stage I, and the possibility of invasion depth was high, that is, the increase of ALI in gastric cancer patients indicatedthat the tumor was in the early stage.Conclusion In patients with gastric cancer, the lower the ALI value, the deeper the tumor inva-sion, the more lymph node metastasis, the larger the tumor diameter and the later TNM stage, the worse the prognosis. |
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