| 张林娜,冯文.绝经后子宫内膜癌病人卵巢静脉血清雌二醇、睾酮及癌胚抗原水平与微卫星状态的相关性分析[J].安徽医药,2023,27(5):967-971. |
| 绝经后子宫内膜癌病人卵巢静脉血清雌二醇、睾酮及癌胚抗原水平与微卫星状态的相关性分析 |
| Correlation analysis of microsatellite status and levels of estradiol, testosterone, CEA in ovarian vein in postmenopausal patients with endometrial carcinoma |
| |
| DOI：10.3969/j.issn.1009-6469.2023.05.026 |
| 中文关键词: 子宫内膜肿瘤 性激素 微卫星状态 癌胚抗原 临床病理特征 |
| 英文关键词: Endometrial neoplasms Sex hormones Microsatellite status Carcinoembryonic antigen Clinicopathological characteristics |
| 基金项目:连云港市妇幼健康科研项目( F202005) |
|
| 摘要点击次数: 752 |
| 全文下载次数: 260 |
| 中文摘要: |
| 目的探讨绝经后子宫内膜癌( EC)病人血清雌二醇(E2)、睾酮(T)及癌胚抗原( CEA)水平与临床病理特征及微卫星状态的相关性。方法选取 2020年 11月至 2021年 10月徐州医科大学附属连云港医院绝经后子宫内膜癌手术治疗病人 62例为观察组，另外选择同期入院的绝经后子宫内膜正常手术治疗病人 60例为对照组。检测两组卵巢静脉血中雌二醇、睾酮及 CEA水平，分析其与子宫内膜癌临床病理特征的相关性，并探讨其与微卫星状态的关系。结果观察组绝经年龄更高［( 52.35±2.50)岁比(49.92±4.01)岁］体质量指数( BMI)更高［( 27.28±4.59)kg/m2比( 24.85±2.86)kg/m2］子宫内膜厚度更大［( 10.20±5.07)mm比( 4.46±2.33)mm］，异有统计学意义( P<0.05)；在卵巢静脉血中，观察组雌二醇［±9.63)ng/L比( 31.23±17.66) ng/L］、睾酮［(110.07±29.63)ng/dL比( 72.77±41.22)ng/dL］及 CEA［(14.38±2.52)μg/L比( 4.21±1.81)μg/L］水平高于对照组，差异有统计学意义(P<0.05)。观察组病人卵巢静脉血清睾酮及雌二醇水平与肿瘤 FIGO分期、肌层浸润深度呈负相关( P<0.05)观察组病人卵巢静脉血 CEA水平与肿瘤 FIGO分期、分化程度呈正相关(P<0.05)与肌层浸润深度呈负相关(P<0.05)。观察微卫星不稳定( MSI)病人卵巢静脉血睾酮、雌二醇及 CEA水平高于微卫星稳MSS)病人，差异有统计学意义( P<0.05)。结论绝经后子宫内膜癌病人卵巢静脉血中雌二醇、睾酮及 CEA水平明显高于子宫内膜正常病人，且与 EC的病理特征相关，睾差，(58.03，组中，定(酮、雌二醇及 CEA水平与子宫内膜癌微卫星状态相关。 |
| 英文摘要: |
| Objective To investigate the correlation between the levels of estradiol (E2), testosterone (T) and carcinoembryonic anti-gen (CEA) and clinicopathological characteristics as well as microsatellite status in postmenopausal patients with endometrial carcino-ma (EC).Methods Sixty-two patients with postmenopausal EC undergoing surgery in The Affiliated Lianyungang Hospital of XuzhouMedical University from November 2020 to October 2021 were selected as the study group, and 60 patients with normal postmenopaus-al endometrium undergoing surgery during the same period were selected as the control group. The levels of E2, T and CEA in ovarianvenous blood of the two groups were detected to analyze the relationship between them and the clinicopathological characteristics ofEC, and to explore their correlation with microsatellite status of EC.Results Patients in the study group had older age of menopause [(52.35±2.50) years vs. (49.92±4.01) years], higher body mass index (BMI) [(27.28±4.59) kg/m2 vs. (24.85±2.86) kg/m2] and thicker en-dometrial thickness [(10.20±5.07) mm vs. (4.46±2.33) mm], and the differences were statistically significant (P<0.05). The levels of E2 [(58.03±9.63) ng/L vs. (31.23±17.66) ng/L], T [(110.07±29.63) ng/dL vs. (72.77±41.22) ng/dL] and CEA [(14.38±2.52) μg/L vs. (4.21± 1.81) μg/L] in the study group were higher than those in the control group, and the differences were statistically significant (P<0.05). The levels of serum T and E2 in ovarian vein were negatively correlated with tumor FIGO staging and the depth of myometrial invasion in the study group (P<0.05), while the level of CEA in ovarian venous blood was positively correlated with tumor FIGO staging and dif-ferentiation degree in the study group (P<0.05), and was negatively correlated with the depth of myometrial invasion (P<0.05). In the study group, the levels of T, E2 and CEA in ovarian venous blood of microsatellite instability (MSI) patients were higher than those of mi-crosatellite stability (MSS) patients, and the differences were statistically significant (P<0.05). Conclusion The levels of E2, T andCEA in ovarian venous blood of postmenopausal patients with endometrial cancer are significantly higher than those of patients with normal endometrium, which are correlated with the pathological features of EC as well as the microsatellite status of endometrial cancer. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
