| Objective To explore the clinicopathological features of chromophobe cell carcinoma of the kidney.Methods Data of 11 cases of chromophobe cell carcinoma, diagnosed in The First Medical Center of the PLA General Hospital from February 2017 toDecember 2020, were collected to summarize their clinicopathological features and to review the literature. Results Which was slightly more common in men and on the right. The section was nodular. Under the microscope, the cells had a clear cell membrane,most of which were arranged in a flat shape, a few in an acinar shape, and the nuclei were often wrinkled raisin-like. The cytoplasm wasrich, lightly stained and translucent, and some cytoplasm was eosinophilic, and perinuclear translucent halo was often seen. Thickwalled small blood vessels could be seen. There was scattered punctate calcification, and no distinct tumor necrosis was found. Immuno-histochemistry showed that CD117 and CK7 were mostly positive, CD10 partially positive, EMA positive, CK20 positive (4/4), Ksp-cad-herin positive, and S-100A1 mostly negative. Ki67 index was low (ranging from 1% to 5%) with an average of 2.2%. It was necessary todistinguish it from a variety of renal tumors.Conclusions Chromophobe cell carcinoma has unique morphological and immunohisto-chemical characteristics. The tissue morphology shows a clear cell membrane, bright cytoplasm, shrunk nucleus and halo nucleus. Im-munohistochemistry shows that S-100A1 is negative, CD117 and CK7 are often positive, and Ki67 index is low, which indicates thatchromophobe cell carcinoma is a malignant tumor with inert biological behavior. |
