| 徐佳贝,皮洁,赵玉字,等.原发性阴道绒毛管状腺癌 1例并文献复习[J].安徽医药,2023,27(5):1003-1006. |
| 原发性阴道绒毛管状腺癌 1例并文献复习 |
| One case report about primary vaginal villoglandular adenocarcinoma with literature review |
| |
| DOI：10.3969/j.issn.1009-6469.2023.05.035 |
| 中文关键词: 阴道肿瘤 原发性阴道绒毛管状腺癌 肠型腺癌 治疗 诊断 文献复习 |
| 英文关键词: Vaginal neoplasms Primary vaginal villoglandular adenocarcinoma Intestinal adenocarcinoma Treatment Diag-nosis Literature review |
| 基金项目: |
|
| 摘要点击次数: 683 |
| 全文下载次数: 299 |
| 中文摘要: |
| 目的结合文献报告 1例原发性阴道绒毛管状腺癌病例。方法对武汉大学人民医院妇一科 2018年 11月至 2020年 11月收治的 1例原发性阴道绒毛管状腺癌进行报道并文献复习。结果女， 40岁，以同房后出血 1年收入院，妇科检查及阴道镜检查示阴道壁肿物，予行阴道壁肿物活检，病理示阴道绒毛管状腺癌， FIGO分期为 ⅡB期，影像学检查排除转移性肿瘤可能。免疫组化结果细胞角蛋白(CK)20(+)、 CK7(+)、P16(+)、绒毛蛋白( Villin)(+)、 p53(野生型)、 Ki-67(+，约 90%)，特异 AT序列结合蛋白 2(SATB2)(.)。予以 TC方案新辅助化疗 2周期，效果可，建议病人行广泛全子宫切除术 +全阴道切除术 +盆腔淋巴结及腹股沟淋巴结切除术，病人拒绝，遂行盆腔外照射、腔内放疗联合组织间插值放疗，复查结果可，定期随访。结论原发性阴道绒毛管状腺癌罕见，易于混淆，需仔细排除其他来源肿瘤转移可能，诊断的金标准是病理学检查，治疗方案应根据临床 FI-GO分期、肿瘤部位及病理类型合理选择，遵循个体化原则，以手术、放疗为主，化疗为辅，建议在其初次治疗后进行密切随访以获得最佳生存时间。 |
| 英文摘要: |
| Objective To report a case of primary vaginal villoglandular adenocarcinoma in combination with literature.Methods A case of primary vaginal villous tubular adenocarcinoma admitted to the First Department of Gynecology, Renmin Hospital of WuhanUniversity from November 2018 to November 2020 was reported and literature review was conducted.Results The 40-year-old female patient was admitted into our hospital for 1 year with hemorrhage after sexual intercourse. Gynecological examination and colposcopyshowed vaginal wall mass and vaginal wall mass biopsy was performed. The pathologic results showed vaginal villoglandular adenocarci-noma, FIGO stage Ⅱ B, and imaging examination excluded the possibility of metastatic tumor. Immunohistochemical results showedCK20 (+), CK7(+), P16 (+), Villin (+), p53 (wild type), Ki-67 (+, 90%), SATB2 (.). TC regimen neoadjuvant chemotherapy was given for2 cycles, and the effect was satisfactory. Extensive hysterectomy + total vaginectomy + pelvic lymph node and inguinal lymph node re-section were recommended, but the patient refused, so we gave her external pelvic irradiation, intraluminal radiotherapy combined withintertissue interpolation radiotherapy. Review results were good, regular follow-up was conducted.Conclusions Primary vaginal villo-glandular adenocarcinoma is rare and easy to confuse, the possibility of tumor metastasis from other sources should be carefully exclud-ed. The gold standard for diagnosis is pathological examination. Treatment should be reasonably selected according to clinical FIGOstage, tumor site and pathological type. In accordance with the principle of individuation, surgery and radiotherapy were the main treat-ment, supplemented by chemotherapy. Close follow-up was recommend after initial treatment for optimal survival. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
