| 李晶晶,孙文军.基于文献数据挖掘探析中药治疗血管性痴呆的用药规律[J].安徽医药,2023,27(6):1077-1082. |
| 基于文献数据挖掘探析中药治疗血管性痴呆的用药规律 |
| Exploring the dosing pattern of traditional Chinese medicine for vascular dementia based on literature data mining |
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| DOI：10.3969/j.issn.1009-6469.2023.06.005 |
| 中文关键词: 痴呆，血管性 中草药 药对 数据挖掘 文献研究 |
| 英文关键词: Dementia, vascular Drugs, Chinese herbal Couplet medicines Data mining Literature study |
| 基金项目:北京中医药大学重点攻关课题( 2020-JYB-ZDGG-144-2)；北京中医药大学重点攻关项目( 2020-JYB-ZDGG-144)；北京藏医院“心脑血管临床和民族医技医法传承及新药开发研究”之子课题( 2016ZYY-SY01)；中国民族医药学会课题( 2019KYXM-M105-141)；中国民族医药学会课题( 2019KYXM-Z1148-142)；中国卒中学会课题( 2021ZGZZXH156)；首发科研专项( 2022-2-7035) |
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| 中文摘要: |
| 目的采取数据挖掘方法，探析中药治疗血管性痴呆( VaD)的组方配伍规律。方法收集中国知网、维普数据库、 PubMed等数据库自建库日至 2022年 3月 1日中关于中医或中西医治疗 VaD的临床研究中的内服处方，建立 VaD方剂数据库，并运用频次及使用剂量统计、聚类分析、关联规则等方法，探索组方配伍规律。结果共纳入 302篇文献，涉及内服方剂 334首，中药 185味，得到频次 ≥40的中药 29味。挖掘出核心中药为石菖蒲、川芎、远志、熟地黄、黄芪。得到熟地黄 -肉苁蓉、远志山药、石菖蒲 -人参、黄芪 -当归、石菖蒲 -天南星、石菖蒲 -郁金、川芎 -地龙 9对药物配伍，总结出高频药物组合四组。结论 VaD的病机在脑，与精血相关，涉及肾精亏虚、气血两虚、血瘀阻络、痰蒙神窍等证型。中医药治疗 VaD注重补肾益精、补气养血，并标本兼治，辅以豁痰开窍、祛瘀通络、清热化痰等治法。 |
| 英文摘要: |
| Objective A data mining method was adopted to explore the grouping and dispensing pattern of Chinese medicine for vascular dementia.Methods The internal prescriptions in clinical studies on Chinese medicine or Chinese and Western medicine forthe treatment of vascular dementia in databases such as the China Knowledge Network, Vipshop database and PubMed from the date ofdatabase construction to March 1, 2022 were collected to establish a database of prescriptions for vascular dementia, and the groupingand dispensing rules were explored by using frequency and usage dose statistics, cluster analysis and association rules.Results A total of 302 documents were included, involving 334 internal prescriptions and 185 Chinese herbal medicines, and 29 Chinese herbalmedicines with frequencies ≥ 40 were obtained. The core herbs were excavated as Acorus Shi calamus, Chuanxiong, Yuanzhi, Shudi? huang and Huangqi. Nine pairs of drug combinations were obtained for Shudihuang -Cistanches, Yuanzhi -Yam, Shi calamus -ginseng, Huangqi -angelica, Shi calamus -Tiannanxing, Shi calamus -Yujin, and Chuanxiong -Dilong, and four groups of high frequency drug combinations were summarized.Conclusions The pathogenesis of vascular dementia is in the brain and is related to essence andblood, involving deficiency of kidney essence, deficiency of both qi and blood, blood stasis blocking the ligaments, and phlegm cloudingthe nerves. The treatment of vascular dementia in Chinese medicine focuses on tonifying the kidney and essence, nourishing qi andblood, and treating both the symptoms and the root cause, supplemented by expelling phlegm and opening the orifices, dispelling bloodstasis and clearing heat and resolving phlegm. |
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