| 张子杭,成元华,李小梅.纺锤体蛋白、锌指转录因子和紧密连接蛋白表达与胃癌临床病理特征的关系[J].安徽医药,2023,27(6):1159-1161. |
| 纺锤体蛋白、锌指转录因子和紧密连接蛋白表达与胃癌临床病理特征的关系 |
| Relationship among the expression of spindle protein, zinc finger transcription factor and tight junction protein and clinicopathological features of gastric cancer |
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| DOI：10.3969/j.issn.1009-6469.2023.06.022 |
| 中文关键词: 胃肿瘤 纺锤体 紧密连接蛋白质类 锌指转录因子蛋白 相关性 肿瘤分期 蛋白表达 |
| 英文关键词: Stomach neoplasms Spindle apparatus Tight junction protein Slug protein Correlation Tumor stage Protein expression |
| 基金项目:贵州省科技计划(黔合科 J字〔2009〕2187) |
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| 中文摘要: |
| 目的分析胃癌病人癌组织中纺锤体蛋白( SPIN1)、锌指转录因子( Slug)和紧密连接蛋白( Claudin-1)三种蛋白的表达情况与其临床病理特征的相关性。方法选取贵州医科大学附属医院 2019年 6月至 2021年 7月确诊并收治的 84例胃癌病人，按照分期分为对照组(早期胃癌)和实验组(晚期胃癌)两组，使用 ELISA检测胃癌组织中的 SPIN1、Slug和 Claudin-1三种蛋白表达情况并分析其间的关系。结果两组病人在一般资料上差异无统计学意义( P>0.05)在年龄、饮酒史和胃部疾病上差异有统计学意义( P<0.05)实验组胃癌病人 SPIN1和 Slug显著高于对照组胃癌病人( P<0.05)，且实验组 Claudin-1显著低于对照组胃癌病人( P<0.05)，对，照组和实验组的肿瘤长径［ ≥5 mm:4(9.52%)比 32(76.19%)］、是，否存在淋巴结转移［阳性: 5(11.90%)比 37(88.10%)］之间均差异有统计学意义( P<0.05)。结论胃癌病人 SPIN1、Slug和 Claudin-1的表达情况与胃癌分期和肿瘤长径与临床病理特征之间存在一定相关性。 |
| 英文摘要: |
| Objective To analyze the correlation between the expression of three proteins, spindle protein (SPIN1), zinc finger transcription factor (Slug) and tight junction protein (Claudin-1), and their clinicopathological features in tumor tissues of gastric tumor patients.Methods A total of 84 gastric tumor patients diagnosed and admitted to the Affiliated Hospital of Guizhou Medical Universityfrom June 2019 to July 2021 were selected and divided into two groups according to stage: the control group (early gastric tumor) andthe experimental group (advanced gastric tumor). ELISA was used to detect the expression of three proteins, SPIN1, Slug and Claudin1, in gastric tumor tissues and to analyze the relationship between them.Results There was no significant difference in general data between the two groups (P>0.05) and statistically significant differences in age, history of alcohol consumption and gastric diseases (P< 0.05). SPIN1 and Slug were significantly higher in the experimental group than in the control group (P<0.05), and claudin-1 was significantly lower in the experimental group than in the control group (P<0.05). The differences between the tumor diameter [5 mm: 4(9.52%) than 32 (76.19%)] and the presence of lymph node metastasis [positive: 5 (11.90%) and 37 (88.10%)] were significant (P<0.05). Conclusion The expression of SPIN1, Slug and Claudin-1 in gastric tumor patients correlated with gastric tumor stage, tumor size and clinicopathological features. |
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