| 从静,浦丹华,谭容容,等.全孕期增补叶酸与妊娠期糖尿病的关联性研究[J].安徽医药,2023,27(6):1253-1258. |
| 全孕期增补叶酸与妊娠期糖尿病的关联性研究 |
| Association between folic acid supplementation throughout pregnancy and gestational diabetes mellitus |
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| DOI：10.3969/j.issn.1009-6469.2023.06.045 |
| 中文关键词: 叶酸 孕妇 妊娠初期 糖尿病，妊娠 调查和问卷 江苏省 |
| 英文关键词: Folic acid Pregnant women Pregnancy trimester, first Diabetes, gestational Surveys and questionnaires Jiangsu province |
| 基金项目:江苏省妇幼健康科研项目( F201613)；江苏省妇幼保健协会科研项目( FYX202007) |
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| 中文摘要: |
| 目的探讨江苏地区孕妇全孕期增补叶酸对妊娠期糖尿病( GDM)的影响。方法选取 2017年 1月至 2018年 12月间在江苏省分娩的胎龄 ≥28周的产妇。根据是否服用叶酸分为未服叶酸组和服用叶酸组。根据服用叶酸的剂量和时间分为六组:早孕期单纯 0.4 mg/d叶酸( 0.4 mg叶酸)组、早孕期含叶酸 0.4 mg/d的复合维生素( MV+0.4 mg叶酸)组、早孕期含叶酸 0.8 mg/d的复合维生素( MV+0.8 mg叶酸)组、全孕期单纯 0.4 mg/d叶酸( 0.4 mg叶酸)组、全孕期含叶酸 0.4 mg/d的复合维生素(MV+0.4 mg叶酸)组、全孕期含叶酸 0.8 mg/d的复合维生素( MV+0.8 mg叶酸)组。通过问卷调查表，由培训专员收集并记录产妇的一般情况、叶酸增补情况、孕产史、职业和环境因素及 GDM等信息。应用 logistic回归及 χ2检验等方法对全孕期叶酸增补情况与 GDM的相关性进行统计分析。结果共纳入 10 662例产妇，未服叶酸组与服用叶酸组 GDM的发生率分别为9.7%(100/1 028)、10.5%(1 014/9 634)，差异无统计学意义。与未服叶酸组相比，无论是否校正协变量，全孕期增补叶酸的女性发生 GDM的风险显著增加，尤其是年龄小于 35岁、孕前体质量指数( BMI)在正常范围及有分娩史的女性。结论孕期叶酸增补应适量，全孕期增补叶酸的女性发生 GDM风险增加。 |
| 英文摘要: |
| Objective To investigate the effect of folic acid (FA) supplementation throughout pregnancy on gestational diabetes mellitus (GDM) in Jiangsu Province.Methods The women of gestational age ≥28 weeks who gave birth in Jiangsu Province between January 2017 and December 2018 were selected. They were divided into non-FA group and FA group according to whether they took FA.According to the dose and time of taking FA, the participants were divided into six groups: 0.4 mg FA (0.4 FA) in early pregnancy, multivitamins with 0.4 mg FA (MV + 0.4 FA) in early pregnancy, multivitamins with 0.8 mg FA (MV + 0.8 FA) in early pregnancy, 0.4 mg FA (0.4 FA) in whole pregnancy, multivitamins with 0.4 mg FA (MV + 0.4 FA) in whole pregnancy, multivitamins with 0.8 mg FA (MV+ 0.8 FA) in whole pregnancy. General information of pregnant women, health status, FA intake during the gestation, maternal history,occupational and environmental factors and GDM were collected through face-to-face interview by trained doctors or midwives. Logistic regression and chi-square test were used to analyze the relationship between the dose and time of FA supplementation and GDM.Results A total of 10 662 puerpera were included. The incidence of GDM in the non-FA group and the FA group was 9.7 % (100/1 028)and 10.5 % (1 014/9 634), respectively, with no significant difference. Compared with non-FA group, the risk of GDM was significantly increased in FA group throughout pregnancy with or without adjustment for covariates, especially in women under the age of 35, with apreconception BMI in the normal range, and with a history of childbirth.Conclusion FA supplementation during pregnancy should be appropriate, and the risk of GDM is increased in pregnant women who take FA supplement daily throughout pregnancy. |
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