| 刘凡凡,张越强,杨文静,等.钠-葡萄糖协同转运蛋白 2抑制剂治疗晚期心力衰竭 1例[J].安徽医药,2023,27(6):1258-1262. |
| 钠-葡萄糖协同转运蛋白 2抑制剂治疗晚期心力衰竭 1例 |
| A case of sodium-glucose cotransporter 2 inhibitor for advanced heart failure |
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| DOI：10.3969/j.issn.1009-6469.2023.06.046 |
| 中文关键词: 心力衰竭 钠 -葡萄糖协同转运蛋白 2抑制剂 卡格列净 利尿 病例报告 |
| 英文关键词: Heart failure Sodium-glucose cotransporter protein 2 inhibitor Kagliflozin Diuresis Case report |
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| 中文摘要: |
| 目的探讨晚期心力衰竭治疗策略。方法报告钠 -葡萄糖协同转运蛋白 2(SGLT2)抑制剂治疗晚期心力衰竭病人 1例。该晚期心力衰竭病人合并多种并发症，应用多种利尿剂效果不佳后给予口服 50 mg卡格列净，每日 1次。结果病人心力衰竭症状得以改善， N末端 -B型钠尿肽前体( NT-proBNP)短期内下降及肾小球滤过率( eGFR)短期上升。结论 SGLT2抑制剂对晚期心力衰竭病人的治疗，短期有效，前景可期。 |
| 英文摘要: |
| Objective To explore the treatment strategy for advanced heart failure.Methods We report a case of advanced heart failure (HF) treated with a sodium-glucose cotransporter 2 (SGLT2) inhibitor. The patient with advanced heart failure had multiple complications and was given an oral dose of 50 mg of Cagliflozin once daily after the ineffective use of multiple diuretics.Results The patients showed improvement in heart failure symptoms, a short-term decrease in N-terminal-B type natriuretic peptide precursor (NTproBNP) and a short-term increase in estimated glomerular filtration rate (eGFR). Conclusion SGLT2 inhibitors are promising for short-term effectiveness in the treatment of patients with advanced heart failure. |
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