文章摘要
张春波,徐曼,段季虹,等.阿莫西林致 Stevens-Johnson综合征 13例分析[J].安徽医药,2023,27(6):1268-1272.
阿莫西林致 Stevens-Johnson综合征 13例分析
Analysis of 13 cases of Stevens-Johnson syndrome caused by amoxicillin
  
DOI:10.3969/j.issn.1009-6469.2023.06.048
中文关键词: 阿莫西林  Stevens-Johnson综合征  药物相关性副作用和不良反应  综述文献(主题)
英文关键词: Amoxicillin  Stevens-Johnson syndrome  Drug-related side effects and adverse reactions  Review literature as topic
基金项目:陕西省自然科学基础研究计划项目( 2022JQ-970);西安市卫生健康委员会科研项目( 2021qn03)
作者单位E-mail
张春波 西安市人民医院西安市第四医院药剂科陕西西安 710004  
徐曼 西安市人民医院西安市第四医院药剂科陕西西安 710004  
段季虹 咸阳彩虹医院药剂科陕西咸阳 712021  
张勇 咸阳彩虹医院药剂科陕西咸阳 712021  
薛小荣 西安市人民医院西安市第四医院药剂科陕西西安 710004 xuexiaorong2006@163.com 
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中文摘要:
      目的分析阿莫西林致 Stevens-Johnson综合征( SJS)不良反应的临床特点、处置措施及预后。方法报道 1例阿莫西林致 SJS的不良反应,并检索建库至 2022年 2月国内外公开发表的阿莫西林致 SJS不良反应的个案文献,提取不良反应的临床特征、处置措施及预后等信息进行总结。结果共收集到阿莫西林致 SJS不良反应的文献 11篇,总计病例 12例(连同作者收治的该例,合计阿莫西林致 SJS有 13例)。 SJS的不良反应表现为多形性红斑、皮肤水疱性病变。立即停用可疑药物,给予糖皮质激素,局部对症治疗, 10例预后良好, 2例死亡。结论临床使用阿莫西林时,要询问病人过敏史,必须进行皮肤试验,皮试阴性方可使用。注意其致 SJS的不良反应,症状出现后及时停药,以确保用药安全性。
英文摘要:
      Objective To analyze the clinical characteristics, management and prognosis of Stevens-Johnson syndrome (SJS) caused by amoxicillin.Methods A case of SJS caused by amoxicillin was reported, and the literature of SJS caused by amoxicillin published at home and abroad from the establishment of the database to February 2022 was searched, and the clinical characteristics, management measures and prognosis were extracted and summarized.Results A total of 11 papers on SJS caused by amoxicillin were collected, with a total of 12 cases (together with the case admitted to the author, there were 13 cases of amoxicillin to SJS). The clinical manifestations included erythema multiforme, skin vesicular lesions. The suspected drugs were stopped immediately, glucocorticoid was given, and local symptomatic treatment was performed. The prognosis was good in 10 cases, and 2 cases died.Conclusion When usingamoxicillin in clinical, patients′ history of allergy should be asked, skin test must be carried out, and only if the skin test is negativeshould the drug be administered. Attention should be paid to the adverse reactions caused by SJS, and the drug should be stopped intime after symptoms appear to ensure the safety of the drug.
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