| 陈宗存,赖舒畅,王秋怡,等.合并骨质疏松且无低血镁的 Gitelman综合征 1例[J].安徽医药,2023,27(7):1353-1355. |
| 合并骨质疏松且无低血镁的 Gitelman综合征 1例 |
| Gitelman syndrome with osteoporosis and normal blood magnesium: one case report |
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| DOI：10.3969/j.issn.1009-6469.2023.07.017 |
| 中文关键词: Gitelman综合征 低钾血症 骨质疏松 镁 |
| 英文关键词: Gitelman syndrome Hypokalemia Osteoporosis Blood magnesium |
| 基金项目:海南省自然科学基金面上项目( 821MS138)；海南省重点研发计划项目( ZDYF2021SHFZ080) |
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| 中文摘要: |
| 目的探讨 Gitelman综合征(GS)合并重度骨质疏松的临床特点、诊断和治疗，加深对该病的认识。方法 2017年 2月海南医学院第二附属医院内分泌科住院的 GS合并重度骨质疏松且无低血镁 1例，复习文献，总结该病特点。结果该病主要表现为严重低钾血症、多处骨关节疼痛，易误诊。予积极补钾、抗醛固酮、抗骨质疏松治疗，有效缓解了病情。结论 GS虽然尿钙低，无低血镁，但也可以合并骨质疏松。因此，对存在多关节疼痛的 GS病人，应及时进行双能 X线骨密度检查早期筛查骨质疏松。对于此类病人，积极给予补钾、抗醛固酮及抗骨质疏松治疗可提高疗效。 |
| 英文摘要: |
| Objective To investigate the clinical characteristics, diagnosis and treatment of Gitelman syndrome with osteoporosisand normal blood magnesium.Methods One case of Gitelman syndrome with severe osteoporosis and no hypomagnesium was admitted to the Department of Endocrinology, the Second Affiliated Hospital of Hainan Medical University on February, 2017. The literatureswere reviewed and the characteristics of the disease were summarized.Results The disease was characterized by severe hypokalemia,multiple bone and joint pain, which was easily misdiagnosed. Potassium, aldosterone antagonist and anti-osteoporotic effectively allevi ated the disease.Conclusion Although Gitelman syndrome has low urinary calcium and no low blood magnesium, it can also be associated with osteoporosis. Therefore, Gitelman syndrome patients with multiple joint pain should be promptly screened for osteoporosisby dual-energy X-ray bone density examination. For such patients, active administration of potassium supplement, anti-aldosterone and anti-osteoporosis therapy can improve the curative effect. |
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