| 杨宁,司定然,梁彦丽,等.血管生成素样蛋白 2与血管生成素样蛋白 1比值与急性心肌梗死介入术后支架内再狭窄的关系[J].安徽医药,2023,27(7):1433-1437. |
| 血管生成素样蛋白 2与血管生成素样蛋白 1比值与急性心肌梗死介入术后支架内再狭窄的关系 |
| Relationship between the ratio of Angptl2/Angptl1 and in-stent restenosis after PCI in patients with acute myocardial infarction |
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| DOI：10.3969/j.issn.1009-6469.2023.07.035 |
| 中文关键词: ST段抬高型心肌梗死 冠状动脉再狭窄 血管生成素样蛋白 1 经皮冠状动脉介入术 诊断价值 后发，)为， |
| 英文关键词: ST elevation myocardial infarction Coronary restenosis Angiopoietin-like protein 1 Percutaneous coronary intervention Diagnosis value |
| 基金项目:河南省医学科技攻关联合共建项目( LHGJ20221016) |
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| 中文摘要: |
| 目的探讨血管生成素样蛋白 2与血管生成素样蛋白 1比值( Angptl2/Angptl1)与急性 ST段抬高型心肌梗死( STEMI)病人经皮冠状动脉介入( PCI)术后支架内再狭窄( ISR)的关系。方法选取 2017年 1月至 2020年 9月在濮阳市油田总医院行急诊 PCI的 STEMI病人 221例为研究对象，均术后随访 12个月，按冠状动脉造影检查的结果将其分为狭窄组(发生 ISR的 35例)和未狭窄组(未发生 ISR的 186例)。比较两组一般资料；血清 Angptl1、Angptl2水平，计算 Angptl2/Angptl1；logistic回归分析 STEMI病人 PCI术后 ISR的影响因素；受试者操作特征( ROC)曲线评价 Angptl2/Angptl1诊断 STEMI病人 PCI术后 ISR的价值。结果狭窄组 STEMI病人支架直径、血清 Angptl1水平低于未狭窄组［( 2.92±0.47)mm比( 3.39±0.51)mm，(1.45±0.48)mg/L比(2.01±0.67)mg/L，t=5.06、4.72，P<0.05］，血清 Angptl2水平及 Angptl2/Angptl1高于未狭窄组［(2.54±0.85)mg/L比( 1.78±0.60)mg/ L，1.75±0.59比 0.89±0.30，t=6.39、12.94，P<0.05］； Angptl2/Angptl1［OR 95%CI:2.95(1.76，4.93)P<0.05］是 STEMI病人 PCI术后发生 ISR的危险因素，支架直径［ OR 95%CI:0.58(0.48，0.72)P<0.05］是 STEMI病人 PCI术生 ISR的保护因素； Angptl2/ Angptl1诊断 STEMI病人 PCI术后发生 ISR的曲线下面积(AUC0.90，截断值为 1.31，其灵敏度为 82.9%，特异度为 87.1%。结论 PCI术后 ISR的 STEMI病人 Angptl2/Angptl1较高， Angptl2/Angptl1有望作为诊断 STEMI病人行 PCI术后 ISR的潜在指标。 |
| 英文摘要: |
| Objective To investigate the relationship between angiopoietin like protein 2/ angiopoietin like protein 1 (Angptl2/Angptl1) ratio and in stent restenosis (ISR) after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI).Methods A total of 221 STEMI patients who underwent emergency PCI in Puyang Oilfield General Hospital fromJanuary 2017 to September 2020 were selected as the research objects. All STEMI patients were followed up for 12 months after surgery. According to the results of coronary angiography, they were assigned into stenosis groups (occurring 35 STEMI patients with ISR)and the non-stenosis group (186 STEMI patients without ISR). The general data, serum Angptl1 and Angptl2 level were compared between the stenosis group and the non-stenosis group, and the ratio of Angptl2/Angptl1 was calculated; Logistic regression was used toanalyze the influencing factors of restenosis in STEMI patients after PCI; the receiver operating characteristic (ROC) curve evaluatedthe value of Angptl2/Angptl1 ratio in the diagnosis of ISR after PCI in patients with STEMI.Results The stent diameter and serum Angptl1 level of STEMI patients in the stenosis group were lower than those in the non-stenosis group [(2.92±0.47)mm vs. (3.39±0.51) mm, (1.45±0.48)mg/L vs. (2.01±0.67)mg/L,t=5.06, 4.72,P<0.05], and the serum Angptl2 level and Angptl2/Angptl1 ratio were higher than those of the non-stenosis group [(2.54±0.85)mg/L vs.(1.78±0.60) mg/L,1.75±0.59 vs. 0.89±0.30, t=6.39,12.94, P<0.05]; Angptl2/ Angptl1 ratio [OR 95%CI: 2.95(1.76, 4.93), P<0.05] was a risk factor of ISR in STEMI patients after PCI, stent diameter [OR 95%CI: |
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