| Objective To study the changes of anterior segment biometrics in patients with type 2 diabetes (T2DM), and explore its clinical significance.Methods A total of 180 patients (180 eyes) with T2DM in the First Affiliated Hospital of Hebei North Universityfrom June 2019 to March 2021 were selected and all underwent fundus fluorescein angiography. According to the degree of retinopathy,they were divided into non-diabetic retinopathy (NDR) group, non-proliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group, with 60 cases in each group, and another 60 cases (60 eyes) of healthy physical examination during thesame period were selected as the healthy control group. A-mode ultrasound was used to measure the biological measurements of the anterior segment of the eye, including central corneal thickness (CCT), central anterior chamber depth (ACD), lens thickness (LT) and axial length (AL), Calculate lens position (LP), chamber crowd ratio (CCR), rACD, rLT, r, and detection of glycosylated hemoglobin(HbA1c) levels in patients with T2DM, and compare HbA1c levels with different degrees of retinopathy, four groups and different courses of T2DM The biometric values of the anterior segment of the patient's eyes and the correlation between CCT, ACD, LT, AL and thecourse of HbA1c and course of DM were analyzed. Results There were significant differences in CCT [(559.21±26.53), (545.36±25.12), (532.18±24.35), (520.23±22.36)μm], ACD[(2.35±0.21), (2.48±0.23), (2.60±0.22), (2.77±0.24)mm], LT[(5.03±0.29), (4.88±0.27), (4.56±0.31), (4.32±0.36)mm], AL[(21.95±0.34), (22.55±0.36), (22.84±0.48), (23.18±0.52)mm], CCR[(2.13±0.26), (1.97±0.22),(1.75±0.18), (1.56±0.17)], rLT[(0.23±0.02), (0.21±0.02), (0.20±0.01), (0.18±0.01)], and r[(0.34±0.02), (0.32±0.01), (0.31±0.01), (0.30±0.01)] among the four groups (P<0.05), and the differences were statistically significant between the two groups (P<0.05); The HbA1clevels[(9.87±1.15), (8.56±1.03), (7.84±0.98)%] of PDR group, NPDR group and NDR group were compared, and the difference was statistically significant (P<0.05).; There were statistically significant differences in CCT[(558.36±18.32), (540.36±15.35), (535.01±10.26)], ACD[(2.38±0.16), (2.52±0.12), (2.57±0.08)mm], LT[(4.99±0.18), (4.75±0.16), (4.68±0.14)mm], AL[(22.06±0.20), (22.62±0.21), (22.74±0.24)mm], CCR[(2.16±0.23), (1.88±0.15), (1.82±0.11)], rLT[(0.23±0.02), (0.21±0.02), (0.20±0.01)], and r[(0.33±0.02),(0.32±0.01), (0.31±0.01)] in T2DM patients with different durations of DM (P<0.05), and there were significant differences in pairwise comparison between groups (P<0.05);Pearson correlation analysis showed that CCT and LT were positively correlated with the course ofHbA1c and DM, and ACD, AL were negatively correlated with the course of HbA1c and DM (P<0.05).Conclusions The structure of the anterior segment of T2DM patients changes significantly, showing a tendency of "crowding". The more severe the degree of retinopathy, the more severe the tendency of "crowding", which may be more likely to induce angle closure, and the biometric value of the anterior segment is closely related to the course of DM and HbA1c. |
