| 杜晓琴,马瑛,谢刚,等.B淋巴细胞瘤 -2关联永生基因 3蛋白、多重肿瘤抑制基因 1在宫颈癌癌前病变中表达及联合液基细胞学检查的临床意义[J].安徽医药,2023,27(8):1633-1636. |
| B淋巴细胞瘤 -2关联永生基因 3蛋白、多重肿瘤抑制基因 1在宫颈癌癌前病变中表达及联合液基细胞学检查的临床意义 |
| Expression of BAG3 protein and P16 in patients with cervical precancerous lesions and its clinical significance in combination with liquid based cytology |
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| DOI：10.3969/j.issn.1009-6469.2023.08.031 |
| 中文关键词: 宫颈肿瘤 组织细胞学制备技术 癌前病变 B淋巴细胞瘤 -2关联永生基因 3(BAG3) 联合检测 多重肿瘤抑制基因 1(P16) |
| 英文关键词: Uterine cervical neoplasms Histocytological preparation techniques Precancerous lesions B lymphocytoma-2 as sociated immortality gene 3 (BAG3) Joint detection Multiple tumor suppressor gene 1 (P16) |
| 基金项目:绵阳市科技计划项目( 16S-ZC-04) |
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| 中文摘要: |
| 目的研究 B淋巴细胞瘤 -2关联永生基因 3(BAG3)蛋白、多重肿瘤抑制基因 1(P16)在宫颈癌癌前病变中表达及联合液基细胞学检查的临床意义。方法选择绵阳市中心医院 2015年 6月至 2017年 6月在妇科门诊筛查并确诊的 120例宫颈病变病人为研究对象，根据其病变情况分为两组，其中癌前病变组病人 69例，宫颈癌组病人 51例。对比两组病人的 BAG3、P16水平，将不同严重程度宫颈癌癌前病变病人的 BAG3、P16水平进行比较，分析联合检测效能。结果宫颈癌组病人的 BAG3(2.74±0.37)水平、 P16(1.45±0.38)水平显著高于癌前病变组 BAG3(1.70±0.51)、 P16(0.53±0.16)差异有统计学意义( P<0.05)。不同严重程度宫颈癌癌前病变病人的 BAG3和 P16水平差异有统计学意义( P<0.05)其中宫皮内瘤变 Ⅰ级( CINⅠ)组的 BAG3(1.01±0.24)水平低于 CINⅡ组 BAG3(1.78±0.79)和 CINⅢ组的 BAG3(2.33±0.88，且 CINⅡ组低于 CINⅢ组，差异有统计颈上，)，学意义( P<0.05)； CINⅠ组的 P16(0.21±0.06)水平低于 CINⅡ组 P16(0.45±0.10)和 CINⅢ组的 P16(0.72±0.17)水平，且 CINⅡ组低于 CINⅢ组，差异有统计学意义( P<0.05)。联合诊断对于宫颈癌的诊断特异度显著高于单独检测，差异有统计学意义( P<0.05)。通过 ROC曲线分析结果发现联合检测对于宫颈癌癌前病变的诊断 ROC曲线下面积显著高于单独检测( P<0.05)。结论 随着宫颈癌前病变的进展， P16、BAG3表达增加， BAG3蛋白、 P16联合液基细胞学检查对于病人的诊断具有积极的意义。 |
| 英文摘要: |
| Objective To study the expression of B lymphocytoma-2 associated immortality gene 3 (BAG3) protein, multiple tumorsuppressor gene 1 (P16) in patients with cervical precancerous lesions and the clinical significance of combined liquid based cytology.Methods A total of 120 patients with cervical disease screened and diagnosed in the Gynecological Clinic of Mianyang Central Hospital from June 2015 to June 2017 were selected as the research objects. According to the pathological changes, they were divided intotwo groups, including 69 patients with precancerous lesions and 51 patients with cervical cancer. The levels of BAG3 and P16 in thetwo groups and patients with cervical precancerous lesions of different severity were compared, and the efficacy of combined detection,including levels of BAG3, P16 and liquid based cytology was analyzed.Results The levels of BAG3 (2.74±0.37) and P16 (1.45±0.38)in cervical cancer group were significantly higher than those in precancerous lesion group (1.70±0.51) and P16 (0.53±0.16), with statistical significance (P<0.05).The difference of BAG3 and P16 levels in patients with cervical precancerous lesions of different severitywas statistically significant (P<0.05). The level of BAG3 in CIN Ⅰ group (1.01±0.24) was lower than that in CIN Ⅱ group (1.78±0.79)and CIN Ⅲ group (2.33±0.88), and CIN Ⅱ group was lower than CIN Ⅲ group, the difference was statistically significant (P<0.05).The level of P16 in CIN Ⅰ group (0.21±0.06) was lower than that in CIN Ⅱ group (0.45±0.10) and CIN Ⅲ group (0.72±0.17), and CINⅡ group was lower than CIN Ⅲ group, the difference was statistically significant (P<0.05). The specificity of combined diagnosis for cervical cancer was significantly higher than that of single detection (P<0.05). ROC curve analysis showed that the area under the ROCcurve of combined detection was significantly higher than that of single detection (P<0.05).Conclusion With the progression of cervical precancerous lesions, the expression of p16 and BAG3 increases, and the combination of BAG3 protein and P16 combined with liquid-based cytology is of positive significance for the prediction of patients. |
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