| 邵琳,朱言芳,赵国,等.外周血血小板 /淋巴细胞比值、纤维蛋白原 /白蛋白比值与缺血性卒中静脉溶栓后出血转化的相关性[J].安徽医药,2023,27(8):1637-1641. |
| 外周血血小板 /淋巴细胞比值、纤维蛋白原 /白蛋白比值与缺血性卒中静脉溶栓后出血转化的相关性 |
| Correlation analysis of peripheral blood blood platelet-to-lymphocyte ratio, fibrinogen-to-albu min ratio and hemorrhage transformation after intravenous thrombolysis for ischemic stroke |
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| DOI：10.3969/j.issn.1009-6469.2023.08.032 |
| 中文关键词: 卒中 脑梗死 血小板 /淋巴细胞比值 纤维蛋白原 /白蛋白比值 静脉溶栓 |
| 英文关键词: Stroke Brain infarction Platelet-to-lymphocyte ratio Fibrinogen-to-albumin ratio Intravenous thrombolysis |
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| 中文摘要: |
| 目的探讨缺血性卒中( AIS)病人静脉溶栓后外周血血小板 /淋巴细胞比值( PLR)、纤维蛋白原 /白蛋白比值( FAR)与出血转化( HT)的关系。方法选取 2019年 3月至 2020年 5月在青岛大学附属医院接受静脉溶栓治疗的 133例 AIS病人作为研究组，根据 AIS病人静脉溶栓后是否发生 HT，分为 HT组 20例，非 HT组 113例；分析影响 AIS病人静脉溶栓后 HT发生的因素；检测并比较各组 PLR、FAR大小；使用 ROC曲线分析 PLR、FAR对 AIS病人静脉溶栓后 HT发生的预测价值；采用多因素 lo gistic回归分析 AIS病人静脉溶栓后 HT发生的危险因素。结果 HT组美国国立卫生研究院卒中量表( NIHSS)评分［( 16.20± 4.35)分比( 10.09±3.15)分］、改良 Rankin量表( mRS)评分［(4.55±0.89)分比( 1.33±0.47)分］、空腹血糖( FPG)［(8.91±1.21)mmol/ L比( 7.43±1.10)mmol/L］、纤维蛋白原( FBI)［( 3.56±0.14)g/L比( 3.31±0.11)g/L］、中性粒细胞计数［( 6.92±1.73)×109/L比( 4.55± 1.56)×109/L］、血小板( PLT)［( 210.91±60.15)×109/L比( 180.79±58.71)×109/L］、发病至溶栓时间显著高于非 HT组( P<0.05)，HT组病人淋巴细胞(LYM)白蛋白( ALB)低于非 HT组(P<0.05)；与非 HT组比较， HT组病人外周血 PLR、FAR显著升高( P<0.05)； ROC曲线分析显示， PLR、F、AR联合预测 AIS病人静脉溶栓后 HT发生的曲线下面积( AUC)为 0.92(0.87，0.96)明显高于二者单独预测的 AUC(P<0.05)灵敏度为 97.9%，特异度为 85.2%；多因素 logistic回归分析表明， NIHSS评分、 mRS评分、P，LR、FAR是 AIS病人静脉溶栓后 HT发，生的独立危险因素( P<0.05)。结论 PLR、FAR与 AIS病人静脉溶栓后 HT的发生有关，可作为评估AIS病人静脉溶栓后 HT发生的辅助指标。 |
| 英文摘要: |
| Objective To investigate the relationship between peripheral blood platelet-to-lymphocyte ratio (PLR), fibrinogen-to-al bumin ratio (FAR) and hemorrhagic transformation (HT) in patients with ischemic stroke (AIS) after intravenous thrombolysis.Meth ods A total of 133 AIS patients who received intravenous thrombolysis in the Affiliated Hospital of Qingdao University from March2019 to May 2020 were selected as the study group. According to whether AIS patients had HT after intravenous thrombolysis, theywere assigned into HT group (20 cases) and non-HT group (113 cases); the factors affecting the occurrence of HT after intravenousthrombolysis in AIS patients were analyzed; the PLR and FAR in each group were detected and compared; the predictive value of PLRand FAR on the occurrence of HT after intravenous thrombolysis in AIS patients was analyzed with ROC curve; multivariate logistic regression was used to analyze the risk factors of HT after intravenous thrombolysis in patients with AIS.Results National institute of health stroke scale (NIHSS) score [(16.20±4.35) vs. (10.09±3.15)], modified Rankin scale (mRS) score [(4.55±0.89) vs. (1.33±0.47)], fasting blood glucose (FPG) [(8.91±1.21) mmol/L vs. (7.43±1.10) mmol/L], fibrinogen (FBI) [(3.56±0.14) g/L vs. (3.31±0.11) g/L], neutro phil count [(6.92±1.73)×109/L vs. (4.55±1.56) ×109/L], platelet (PLT) [(210.91±60.15)×109/L vs. (180.79±58.71)×109/L], and time from onset to thrombolysis in the HT group were significantly higher than those in the non-HT group (P<0.05); lymphocytes count (LYM) and albumin (ALB) in the HT group were lower than those in the non-HT group (P<0.05); compared with the non-HT group, the peripheral blood PLR and FAR of the HT group were significantly higher (P<0.05); ROC curve analysis showed that the area under the cure(AUC) of PLR and FAR in predicting HT after intravenous thrombolysis in patients with AIS was 0.92 (0.87, 0.96), which was significantly higher than that predicted by them alone (P<0.05), the sensitivity was 97.9% and the specificity was 85.2%; multivariate logisticregression analysis showed that NIHSS score, mRS score, PLR and FAR were independent risk factors for HT after intravenous thrombolysis in AIS patients (P<0.05).Conclusion PLR and FAR are related to the occurrence of HT after intravenous thrombolysis in AISpatients,and they can be used as auxiliary indicators for the occurrence of HT after intravenous thrombolysis in AIS patients. |
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