| 王小波,骆华,刘琛.血清视黄醇结合蛋白 4、胱抑素 C在肾结石术后尿路感染中表达及临床意义[J].安徽医药,2023,27(8):1651-1654. |
| 血清视黄醇结合蛋白 4、胱抑素 C在肾结石术后尿路感染中表达及临床意义 |
| Expression and clinical significance of serum RBP4 and CysC in urinary tract infection after kidney stones surgery |
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| DOI：10.3969/j.issn.1009-6469.2023.08.035 |
| 中文关键词: 肾结石 尿路感染 视黄醇结合蛋白 4 胱抑素 C 肾造口术，经皮 |
| 英文关键词: Kidney stones Urinary tract infection Retinol binding protein 4 Cystatin C Nephrostomy,percutaneous |
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| 中文摘要: |
| 目的探究血清视黄醇结合蛋白 4(RBP4)、胱抑素 C(CysC)在肾结石术后尿路感染中表达及临床意义。方法选取 2019年 7月至 2021年 6月德阳市第二人民医院泌尿外科因肾结石行手术的 157例病人为研究对象，根据术后是否发生尿路感染分为感染组( 81例)与非感染组( 76例)；检测感染组病人尿液中病原菌种类；比较两组血清中 RBP4、CysC水平，并分析影响术后尿路感染发生的相关因素。结果 81例肾结石术后尿路感染病人的尿液标本中检测出 79株病原菌，其中 67.09%为革兰阴性菌， 29.11%为革兰阳性菌，真菌仅占 3.80%；感染组血清 RBP4(17.29±4.73)mg/L、CysC(1.58±0.33)mg/L水平高于未感染组 RBP4(11.74±2.01)mg/L、CysC(1.19±0.14)mg/L水平( P<0.05)；感染组血清 RBP4与 CysC水平呈正相关( r=0.80，P<0.001)；术前留置输尿管支架管、手术时间 ≥60 min、术前无抗生素使用、术后输尿管导管留置时长 ≥7 d以及 RBP4、CysC是影响尿路感染发生的独立危险因素(P<0.05)。结论血清 RBP4、CysC在肾结石术后发生尿路感染病人血清中高表达，血清 RBP4与 CysC水平呈正相关， RBP4、CysC水平变化均与术后发生尿路感染有关。 |
| 英文摘要: |
| Objective To explore the expression and clinical significance of serum retinol binding protein 4 (RBP4) and Cystatin C(CysC) in urinary tract infection after kidney stones surgery.Methods One hundred and fifty-seven patients who underwent surgery forkidney stones in the Dedpartment of Urology, the Second People's Hospital of Deyang City from July 2019 to June 2021 were selectedas the research objects. According to whether the patients were complicated with urinary tract infection, they were assigned into infection group (81 cases) and non-infection group (76 cases). The types of pathogenic bacteria in the urine of the infection group were detected; the serum levels of RBP4 and CysC between the two groups were compared, and the related factors affecting the occurrence ofpostoperative urinary tract infection were analyzed.Results A total of 79 pathogenic bacteria were isolated in the urine of 81 patientswith urinary tract infection after renal calculus surgery, of which 67.09% were Gram-negative bacteria, 29.11% were Gram-positive bacteria, and fungi accounted for only 3.80%; the levels of serum RBP4 (17.29±4.73) mg/L and CysC (1.58±0.33) mg/L in the infectiongroup were higher than those in the non-infection group RBP4 (11.74±2.01) mg/L and CysC (1.19±0.14) mg/L (P<0.05); there was a positive correlation between the expression of serum RBP4 and CysC in infection group (r=0.80, P<0.001); preoperative indwelling ofureteral stents, operation duration ≥60 min, preoperative no antibiotics, postoperative indwelling ureteral catheter duration ≥7 d, RBP4and CysC were the independent risk factors for postoperative urinary tract infection (P<0.05).Conclusion The serum levels of RBP4 and CysC are significantly increased in patients with urinary tract infection after renal calculus surgery, and RBP4 are positively correlated with the level of CysC. The changes of RBP4 and CysC levels are related to postoperative urinary tract infection. |
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