| 李研研,关平,杨欣,等.N3系脂肪酸干预对炎症性肠病病人复发风险的影响[J].安徽医药,2023,27(8):1680-1684. |
| N3系脂肪酸干预对炎症性肠病病人复发风险的影响 |
| Effect of N3-series fatty acid intervention on the risk of relapse in patients with inflammatory bowel disease |
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| DOI：10.3969/j.issn.1009-6469.2023.08.042 |
| 中文关键词: 脂肪酸类，不饱和 炎性肠疾病 N3系脂肪酸 粪便钙卫蛋白 复发风险 |
| 英文关键词: Fatty acids,unsaturated Inflammatory bowel diseases N3 fatty acid Fecal Calprotectin Risk of recurrence |
| 基金项目:河北省卫生厅青年科技课题( 20200288) |
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| 中文摘要: |
| 目的探讨 N3系脂肪酸干预对炎症性肠病病人复发风险的影响。方法前瞻性选取 2018年 1月至 2020年 5月于沧州市人民医院就诊的炎性肠病病人 216例，均接受规范化治疗，按照随机数字表法分为对照组 108例，予以常规饮食干预；干预组 108例，在对照组基础上予以 N3系脂肪酸干预；随访观察 12个月，记录两组复发情况，根据病人复发情况分为复发组和非复发组，利用 Cox回归分析明确 N3系脂肪酸干预对炎性肠病病人复发风险的影响。结果随访 12个月，无 1例失访，共 75例病人出现复发，复发率 34.72%；其中干预组 30例复发，复发率( 27.78%)较对照组 45例复发，复发率( 41.67%)低( log-rank χ2= 6.91，P=0.009)；复发组和未复发组 C-反应蛋白( CRP)、红细胞沉降率( ESR)、肿瘤坏死因子 -α(TNF-α)、氧化三甲胺( TMAO)、粪便钙卫蛋白、吸烟比例比较，差异有统计学意义( P<0.05)； Cox回归分析显示: ESR［HR=1.03，95%CI:(1.01，1.05)］、 TNF-α［HR=1.05，95%CI:(1.03，1.07)］、粪便钙卫蛋白［HR=1.03，95%CI:(1.02，1.03)］、 TMAO［HR=1.38，95%CI:(1.12，1.71)］为炎性肠病复发危险因素(均 P<0.05)N3系脂肪酸干预［HR=0.56，95%CI:(0.35，0.90)］为炎性肠病复发风险的保护因素( P<0.05)。结论 N3系脂肪酸干预有助于降，低炎性肠病病人复发风险。 |
| 英文摘要: |
| Objective To explore the effect of N3 fatty acid intervention on the risk of recurrence in patients with inflammatory bow el disease.Methods A total of 216 patients with inflammatory bowel disease who were treated in the People's Hospital of Cangzhoufrom January 2018 to May 2020 were prospectively selected, and all received standardized treatment. According to the random numbertable method, patients were assigned into the control group and the intervention group, 108 cases in the control group received regulardiet intervention; 108 cases in the intervention group were treated with N3 fatty acid intervention on the basis of the control group. Follow up for 12 months, and the recurrence of the two groups was recorded. The patients were divided into a recurrence group and a non-recurrence group according to the recurrence. Cox regression analysis was used to determine the effect of N3 fatty acid intervention onthe recurrence risk of inflammatory bowel disease patients.Results After 12 months of follow-up, no case was lost to follow-up. A totalof 75 patients had recurrence, with a recurrence rate of 34.72%; 30 cases in the intervention group recurred, and the recurrence rate(27.78%) was lower than that of the 45 cases in the control group (41.67%) (log-rank χ2=6.91, P=0.009);C-reactive protein (CRP), eryth rocyte sedimentation rate (ESR), tumor necrosis factor-α (TNF-α), trimethylamine oxide (Trimethylamine N-oxide, TMAO), fecal calpro tectin, and smoking ratio were significantly different (P<0.05); Cox regression analysis showed that ESR [HR=1.03, 95%CI: (1.01, |
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