方芳,严彩霞,方成志,等.亲环素 A/CD147信号通路与新生儿缺氧缺血性脑损伤相关性研究进展[J].安徽医药,2023,27(9):1706-1709. |
亲环素 A/CD147信号通路与新生儿缺氧缺血性脑损伤相关性研究进展 |
Research progress in the relationship between cyclophilin A/CD147 signaling pathway and neonatal hypoxic-ischemic brain damage |
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DOI:10.3969/j.issn.1009-6469.2023.09.003 |
中文关键词: 缺氧缺血,脑 亲环素 A CD147 信号通路 婴儿,新生 |
英文关键词: Hypoxia-ischemia, brain Cyclophilin A CD147 Signaling pathway Infant, newborn |
基金项目:中央引导地方科技发展专项资金(鄂财教发〔2016〕109号);湖北省卫生健康委员会科研项目( WJ2019M84);五师科技计划项目( 2019SF023) |
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中文摘要: |
新生儿缺氧缺血性脑损伤( HIBD)是围产期窒息的严重并发症,影响着病儿的早期存活和远期预后。亲环素 A(Cy- pA)/CD147信号通路参与细胞的增殖、趋化、凋亡、炎症以及神经元代谢等过程,与 HIBD的发生发展密切相关,因此研究 Cy- pA/CD147的作用机制对 HIBD诊断与治疗具有重要意义。该研究阐述了 CypA/CD147的信号通路与缺血缺氧性脑损伤关系最新研究进展,以期为 HIBD的治疗提供新的思路与方向。 |
英文摘要: |
Neonatal hypoxic-ischemic brain damage (HIBD) is a serious complication of perinatal asphyxia, affecting the early surviv- al and long-term prognosis of the newborn. Cyclophilin A (CypA) /CD147 signaling pathway participates in the proliferation, chemotax-is, apoptosis, inflammation, neuronal metabolism and is closely related to the occurrence and development of HIBD. Therefore, the rolemechanism of CypA/CD147 is important for HIBD diagnosis and treatment. This article reviews the latest research progress in the rela-tionship between CypA/CD147 signaling pathway and hypoxic-ischemic brain damage, in order to provide a new idea and direction for the treatment of HIBD. |
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