| 乔雪梅,王莹,刘朝霞,等.G1-熵权法优化欣胃颗粒剂成型工艺的研究[J].安徽医药,2023,27(9):1745-1749. |
| G1-熵权法优化欣胃颗粒剂成型工艺的研究 |
| Optimization of Xinwei granules molding process by G1 entropy weight method |
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| DOI：10.3969/j.issn.1009-6469.2023.09.011 |
| 中文关键词: 工艺学，制药 欣胃颗粒剂 正交试验设计 G1-熵权法 |
| 英文关键词: Technology, pharmaceutical Xinwei granules Orthogonal test design G1 entropy weight method |
| 基金项目:国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教发〔2016〕42号) |
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| 中文摘要: |
| 目的优选欣胃颗粒剂最佳成型工艺，为欣胃颗粒剂的开发利用提供参考。方法 2020年 9月至 2022年 2月，以 G1熵权法确定各指标权重，选取浸膏相对密度、辅料用量和辅料种类为考察因素，采用三因素三水平正交实验，以休止角、颗粒溶化浊度、颗粒吸湿率和颗粒成型收率为考察综合指标，确定欣胃颗粒剂最优成型工艺。结果评价指标休止角、颗粒溶化浊度、颗粒吸湿率和颗粒成型收率的组合权重分别为 0.367 2、0.172 4、0.191 9、0.268 5。欣胃颗粒剂最佳成型工艺为，辅料采用乳糖与可溶性糊精的混合物，最佳配比浸膏与辅料比为 1∶3，浸膏相对密度为 1.20~1.30(80 ℃测)。结论优选的欣胃颗粒剂成型工艺颗粒流动性较好，颗粒成型率高，物料平衡误差可控，工艺稳定可行，可为欣胃颗粒剂的工业化生产提供实验依据。 |
| 英文摘要: |
| Objective To optimize the optimal forming process of Xinwei granules, and to provide references for the development and utilization of Xinwei granules.Methods From September 2020 to February 2022, the weight of each index was determined by G1entropy weight method, and the relative density of the extract, the amount of auxiliary materials and the types of auxiliary materialswere selected as the investigation factors. Three-factor three-level orthogonal experiments were used to determine the angle of repose,particle melting turbidity, particle moisture absorption rate and particle forming yield, which were used as the inspection indexes to de-termine the optimal molding process of Xinwei granules.Results The combined weights of the angle of repose, particle melting turbidi-ty, particle moisture absorption rate and particle forming yield were 0.367 2, 0.172 4, 0.191 9 and 0.268 5 respectively. The optimalforming process of Xinwei granules was as follows: the auxiliary material was a mixture of lactose and soluble starch, the optimal ratio ofthe extract to auxiliary material was 1∶3, and the relative density of the extract was 1.20-1.30 (measured at 80 ℃).Conclusions The preferred Xinwei granules molding process has good particle fluidity and high particle forming rate. The material balance error is con-trollable, and the process is stable and feasible, which can provide experimental basis for the industrial production of Xinwei granules. |
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