| 刘乙君,刘红星,杨永红,等.皮肤自发荧光糖基化产物与老年 2型糖尿病周围神经病变的相关性研究[J].安徽医药,2023,27(9):1761-1766. |
| 皮肤自发荧光糖基化产物与老年 2型糖尿病周围神经病变的相关性研究 |
| The association between autofluorescence of skin advanced glycation end products and diabetic peripheral neuropathy in elderly patients with type 2 diabetes mellitus |
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| DOI：10.3969/j.issn.1009-6469.2023.09.014 |
| 中文关键词: 糖基化终产物，高级 光谱法，荧光 糖尿病， 2型 糖尿病神经病变 皮肤自发荧光 |
| 英文关键词: Glycosylation end products, advanced Spectrometry, fluorescence Diabetes mellitus, type 2 Diabetic neuropa-thies Skin autofluorescence |
| 基金项目:山西省重点研发计划项目( 201903D321024) |
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| 中文摘要: |
| 目的探讨老年2型糖尿病病人皮肤自发荧光( SAF)与周围神经病变( DPN)之间的关系。方法纳入 2022年 8—9月于太原市尖草坪区汇丰社区卫生服务中心体检的 52例老年2型糖尿病病人，收集病人资料，行 DPN检查和 SAF测定。根据 DPN检查结果分为 DPN组( n=21)和非 DPN组(n=31)，比较两组病人 SAF水平并探索 SAF对 DPN的筛查价值。结果(1)与非 DPN组［( 2.27±0.32)AU］相比， DPN组［(2.70±0.94)AU］的 SAF值显著升高( P<0.05)。根据 SAF测量值分为低、中、高 SAF组，结果显示饮酒和血肌酐升高与 SAF升高有关( P<0.05)。(2)调整混杂因素空腹血糖和 HbA1c后，二元 logistic回归分析显示，SAF病人发生 DPN的风险是低 SAF的 6.98倍［ OR=6.98，95%CI:(1.47，33.17)P=0.014］。(3)以 DPN为因变量进行受试者操作高特征曲线( ROC曲线)分析， SAF、空腹血糖联合 HbA1c筛查 DPN的曲线下面积，为 0.77，灵敏度为 66.7%，特异度为 77.4%。结论 SAF是老年 2型糖尿病病人发生 DPN的独立危险因素，作为一种新型无创标志物，可联合空腹血糖和 HbA1c发挥筛查 DPN的作用。 |
| 英文摘要: |
| Objective This study aimed to investigate the association between skin autofluorescence (SAF) and diabetic peripheralneuropathy (DPN) in elderly patients with type 2 diabetes mellitus.Methods Fifty-two elderly patients with type 2 diabetes mellitustested in Huifeng community health service center in Jiancaoping district in Taiyuan were included in the study. Basic information wascollected, and DPN examination and SAF measurement were performed. The patients were divided into a DPN group (n=21) and a non-DPN group (n=31) based on the results of DPN examination to compare SAF levels and explore the screening value of SAF for DPN.Re- sults (1) SAF values were significantly higher in the DPN group [(2.70±0.94)AU] than the non-DPN group [(2.27±0.32)AU], with a statistically significant difference (P<0.05). The participants were further divided into low, moderate, and high SAF groups, which re-vealed that alcohol consumption and hypertriglyceridemia were associated with elevated SAF with statistically significant differences (P <0.05). (2) After adjusting for confounding factors such as fasting glucose and HbA1c, binary logistic regression analysis showed thatSAF was an independent risk factor for DPN [OR=6.98,95%CI: (1.47,33.17),P=0.014]. (3) The ROC curves were plotted with DPN asthe dependent variable, and the area under the curves for SAF combined with fasting glucose and HbA1c screening for DPN was 0.77,with a sensitivity of 66.7% and a specificity of 77.4%.Conclusion SAF, a novel non-invasive marker, is an independent risk factor for DPN in elderly patients with type 2 diabetes mellitus and can be used in combination with fasting glucose and HbA1c screenings forDPN. |
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