| 张蕊,王健,王艳华,等.经尿道钬激光前列腺剜除术在良性前列腺增生中的应用及对尿动力学、性功能、氧化应激的影响[J].安徽医药,2023,27(9):1819-1823. |
| 经尿道钬激光前列腺剜除术在良性前列腺增生中的应用及对尿动力学、性功能、氧化应激的影响 |
| Application of holmium laser enucleation of the prostate in benign prostatic hyperplasia and its influence on urodynamics, sexual function and oxidative stress |
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| DOI：10.3969/j.issn.1009-6469.2023.09.027 |
| 中文关键词: 前列腺增生 经尿道钬激光前列腺剜除术 前列腺电切术 超声参数 氧化应激 |
| 英文关键词: Prostatic hyperplasia Holmium laser enucleation of the prostate Resection of the prostate Ultrasound parame-ters Oxidative stress |
| 基金项目:承德市科技支撑项目( 202006A021) |
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| 中文摘要: |
| 目的探讨经尿道钬激光前列腺剜除术( HoLEP)在良性前列腺增生( BPH)中的应用及对尿动力学、性功能、氧化应激的影响。方法前瞻性选取 2019年 1月至 2021年 1月承德市中心医院 126例 BPH病人，以随机数字表法分为对照组和试验组，各 63例。对照组行前列腺电切术( TURP)试验组行 HoLEP。观察两组手术情况、并发症、性功能，比较手术前后氧化应激指标［红细胞免疫复合物花环率( RBC-ICR)、红细，胞黏附肿瘤细胞花环率( TRR)］、尿动力学指标［膀胱内残余尿量( PVR)、最大尿流率( Qmax)、生活质量量表( QOL)、国际前列腺症状评分表( IPSS)］、超声参数［阻力指数、加速指数］。结果试验组手术时间、膀胱冲洗时间、导尿管留置时间短于对照组，术中出血量［( 90.23±7.68)mL］小于对照组［( 125.51±12.25)mL］(P<0.05)；术后3d试验组血清 RBC-ICR［(32.26±3.27)%］低于对照组［(36.11±3.19)%］TRR［(23.38±4.12)%］高于对照组［(17.35±2.06)%］(P<0.05)；术后 6个月试验组 IPSS评分、加速指数低于对照组，阻力指数(0.50±0.05)小于对照组( 0.59±0.06)，Qmax大于对照组( P<0.05)；术后 6个月两组 QOL评分［(1.26±0.41)分比( 1.32±0.37)分］、 PVR比较差异无统计学意义( P>0.05)；两组并发症及术后 6个月阴茎勃起强度比较差异无统计学意义( P>0.05)。结论 HoLEP可缩短 BPH病人手术时间，减少术中出血量，改善尿动力学指标及超声参数，改善排尿症状，且对氧化应激影响较小。 |
| 英文摘要: |
| Objective To explore the application of holmium laser enucleation of the prostate (HoLEP) in benign prostatic hyperpla-sia (BPH) and its effect on urodynamics, sexual function, and oxidative stress.Methods A total of 126 patients with BPH admitted toChengde Central Hospital from January 2019 to January 2021 were prospectively selected and assigned into control group and experi-ment group by randomized number table grouping, with 63 cases in each group. The control group underwent transurethral resection ofthe prostate (TURP), and the experiment group underwent HoLEP. We observed the operation conditions, complications, and sexualfunction of the two groups, and compared the oxidative stress indicators [red blood cell immune complex rosette rate (RBC-ICR), RBCadhesion tumor cell rosette rate (TRR)], urodynamic indicators [postvoid residual (PVR), maximum urinary flow rate (Qmax), quality oflife (QOL), International Prostate Symptom Score (IPSS)], ultrasound parameters [resistance index (RI), acceleration index (AI)] beforeand after the operation.Results The operation time, bladder flushing time, and catheter indwelling time in the experiment group wereshorter than those in the control group, and the intraoperative blood loss [(90.23±7.68) mL] was less than that of the control group[(125.51±12.25) mL](P<0.05). On the 3rd day after surgery, the serum RBC-ICR [(32.26±3.27) %] of the experiment group was lowerthan that of the control group [(36.11±3.19) % ], and the TRR [(23.38±4.12) % ] was higher than that of the control group [(17.35±2.06) %] (P<0.05). Six months after surgery, the IPSS score and acceleration index of the experiment group were lower than those of thecontrol group, while the resistance index was lower than that of the control group (0.50±0.05 vs. 0.59±0.06), and the Qmax was higher than that of the control group (P<0.05); there were no statistically significant differences in QOL score (1.26±0.41 vs. 1.32±0.37) and PVR between the two groups 6 months after surgery (P>0.05); there were no statistically significant differences in the complications andpenile erection intensity 6 months after surgery between the two groups (P>0.05).Conclusion HoLEP can shorten the operation timeof patients with BPH, reduce intraoperative blood loss, improve urodynamic indexes and ultrasound parameters, control prostate symp-toms, and have little effect on oxidative stress. |
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