| 李建平,赵磊,田艳伟,等.冷冻联合 A型肉毒毒素与单独 A型肉毒毒素治疗瘢痕疙瘩的疗效比较:前瞻性随机对照研究[J].安徽医药,2023,27(9):1836-1839. |
| 冷冻联合 A型肉毒毒素与单独 A型肉毒毒素治疗瘢痕疙瘩的疗效比较:前瞻性随机对照研究 |
| Efficacy of freezing combined with botulinum toxin type A versus botulinum toxin type A alone in the treatment of keloids: a prospective randomized controlled trial |
| |
| DOI：10.3969/j.issn.1009-6469.2023.09.031 |
| 中文关键词: 瘢痕疙瘩 冷冻疗法 A型肉毒毒素 疗效 |
| 英文关键词: Keloid Cryotherapy Botulinum toxin type A Curative effect |
| 基金项目:承德市科学技术局资助项目( 202109A100) |
|
| 摘要点击次数: 383 |
| 全文下载次数: 260 |
| 中文摘要: |
| 目的比较冷冻联合 A型肉毒毒素与单独 A型肉毒毒素治疗瘢痕疙瘩的疗效。方法选择 2017年 4月至 2020年 4月期间中国人民解放军联勤保障部队第九八一医院收治的瘢痕疙瘩病人 98例为该研究对象，按照随机数字表法将其分成两组，对照组 49例给予 A型肉毒毒素治疗，研究组 49例在对照组基础上联合冷冻进行治疗。比较两组疗效、瘢痕厚度、瘢痕面积、痒程度、不良反应发生率、复发情况。结果研究组总有效率 93.88%(46/49)高于对照组 71.43%(35/49)(P<0.05)。治疗后，痛组瘢痕厚度、瘢痕面积、痛痒程度均低于治疗前(P<0.05)且治疗后研究组瘢痕厚度、瘢痕面积、痛痒程度低于对照组(P<0.05)。两研究组不良反应总发生率 12.24%(6/49)与对照组 10.20%(，5/49)相较，差异无统计学意义( P>0.05)。在完整治疗后为期 6个月随访，对照组复发 12例，研究组复发 8例，研究组复发率 16.33%与对照组 24.49%相较，差异无统计学意义( P>0.05)。结论冷冻联合 A型肉毒毒素治疗瘢痕疙瘩疗效肯定，能改善瘢痕厚度、瘢痕面积、痛痒程度，并且不会明显增加不良反应发生率、复发率。 |
| 英文摘要: |
| Objective Comparison of the efficacy of freezing combined with botulinum toxin type A versus botulinum toxin type Aalone in the treatment of keloids. Methods A total of 98 keloid patients admitted to the No. 981 Hospital, Joint Logistics SupportForce of the Chinese People's Liberation Army from April 2017 to April 2020 were selected as the subjects of this study and were divid-ed into two groups according to the randomized numerical table method, with 49 cases in the control group given botulinum toxin type Aand 49 cases in the study group treated with combined freezing on the basis of the control group. The two groups were compared interms of efficacy, scar thickness, scar area, degree of pain and itching, incidence of adverse reactions and recurrence.Results The to- tal effective rate of the study group was 93.88% (46/49), which was higher than that of the control group (71.43%, 35/49) (P<0.05). Af-ter treatment, the scar thickness, scar area, and degree of pain and itching in the two groups were lower than before treatment (P<0.05),and after treatment, the scar thickness, scar area, pain and itching degree of both groups were lower than that before treatment (P< 0.05), and the scar thickness, scar area, pain and itching degree of the study group was lower than that of the control group after treat-ment (P<0.05). The total incidence of adverse reactions in the study group was 12.24% (6/49) compared with 10.20% (5/49) in the con-trol group, and the difference was not statistically significant (P>0.05). At the 6-month follow up after complete treatment, there were 12recurrences in the control group and 8 recurrences in the study group, with a recurrence rate of 16.33% in the study group comparedwith 24.49% in the control group, and the difference was not statistically significant (P>0.05).Conclusion The efficacy of freezingcombined with botulinum toxin type A in the treatment of keloid scars is certain, and it can improve the scar thickness, scar area, painand itchiness without significantly increasing the incidence of adverse reactions or recurrence rates. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
