| 金立娟,户月,王丽,等.角质细胞生长因子对人工流产术后子宫内膜的修复作用及对月经转归、卵巢排卵的影响[J].安徽医药,2023,27(9):1870-1873. |
| 角质细胞生长因子对人工流产术后子宫内膜的修复作用及对月经转归、卵巢排卵的影响 |
| Repair effect of keratinocyte growth factor on the endometrium after induced abortion and its influence on menstrual regression and ovarian ovulation |
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| DOI：10.3969/j.issn.1009-6469.2023.09.039 |
| 中文关键词: 角质细胞生长因子 排卵 人工流产术 子宫内膜 月经转归 |
| 英文关键词: Keratinocyte growth factor Ovulation Artificial abortion Endometrium Menstrual regression |
| 基金项目:河北省医学科学研究重点课题计划项目( 20201414) |
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| 中文摘要: |
| 目的探讨角质细胞生长因子( KGF)对人工流产术后子宫内膜的修复作用及对月经转归、卵巢排卵的影响。方法选取 2019年 12月至 2020年 12月在石家庄市人民医院行人工流产术的早孕妇女 120例，将所有孕妇按随机数字表法分为观察组 60例，对照组 60例，对照组采用玻璃酸钠治疗，观察组采用 KGF治疗，观察并统计两组的阴道出血天数和月经复潮时间，采用彩色多普勒超声诊断仪对两组子宫动脉阻力指数、血流量、搏动指数、收缩末期血流峰值 /舒张末期血流峰值( S/D)、平均流速血流动力学参数进行测评，采用腹部 B超检查两组的子宫内膜厚度变化情况，统计两组的卵巢恢复排卵例数。 B超检查两组的宫腔粘连程度。结果观察组阴道出血天数( 4.62±0.23)d和月经复潮时间( 28.12±2.06)d均短于对照组( 6.23±0.55)d、(34.12±2.16)d(P<0.05)；治疗后，对照组阻力指数、搏动指数、血流量、平均流速、 S/D均显著降低( P<0.05)，且观察组治疗后上述指标均高于对照组( P<0.05)；观察组子宫内膜厚度( 9.36±1.09)mm大于对照组( 6.22±1.11)mm(P<0.05)；观察组卵巢恢复排卵例数 22例多于对照组 6例( P<0.05)；观察组宫腔粘连程度低于对照组(P<0.05)。结论 KGF治疗可有效改善人工流产术后月经转归情况，稳定术后血流动力学，促进子宫内膜修复和卵巢排卵功能的恢复。 |
| 英文摘要: |
| Objective To investigate the effect of keratinocyte growth factor (KGF) on the repair of the endometrium after inducedabortion and its effect on menstrual regression and ovarian ovulation.Methods A total of 120 early pregnant women who underwent in-duced abortion in Shijiazhuang People's Hospital from December 2019 to December 2020 were selected. All pregnant women were ran-domly divided into 60 cases in the observation group and 60 cases in the control group according to the random number table method.The control group was treated with sodium hyaluronate and the observation group was treated with KGF. The number of days of vaginalbleeding and the time of menstrual rehydration in the two groups were observed and counted. The uterine artery resistance index, bloodflow, pulsatility index, peak end-systolic blood flow/peak end-diastolic blood flow (S/D), and mean flow hemodynamic parameters of thetwo groups were measured by using color Doppler ultrasonography. The changes in endometrial thickness of the two groups were exam-ined using abdominal B-ultrasound, and the number of cases of ovarian ovulation recovery in the two groups was counted. The degree ofintrauterine adhesion in the two groups was examined by B-ultrasound.Results The number of days of vaginal bleeding (4.62±0.23) dand the time of menstrual resumption (28.12±2.06)d in the observation group were shorter than those in the control group [(6.23±0.55)d and (34.12±2.16) d, respectively] (P<0.05). After treatment, the resistance index, pulsatility index, blood flow rate, mean flow rate,and S/D were all significantly reduced in the control groups (P<0.05), and all of the above indicators were higher in the observation group than in the control group (P<0.05). The endometrial thickness of the observed group (9.36±1.09) mm was greater than that of the control group (6.22±1.11) mm (P<0.05); the number of ovarian recovery ovulation cases in the observation group was 22 cases morethan that of the control group (6 cases) (P<0.05); and the degree of intrauterine adhesion in the observation group was lower than that in the control group (P<0.05).Conclusion KGF treatment can effectively improve the menstrual regression after induced abortion, stabi-lize postoperative hemodynamics, and promote the repair of the endometrium and the recovery of ovarian ovulation function. |
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