| 李冰,王慧琴,万燕明,等.吸入用乙酰半胱氨酸溶液联合重组人干扰素 α2b雾化吸入治疗小儿病毒性肺炎 50例疗效观察[J].安徽医药,2023,27(9):1874-1876. |
| 吸入用乙酰半胱氨酸溶液联合重组人干扰素 α2b雾化吸入治疗小儿病毒性肺炎 50例疗效观察 |
| Efficacy of inhaled acetylcysteine solution combined with recombinant human interferon α2b atomization inhalation in the treatment of 50 cases of pediatric viral pneumonia |
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| DOI：10.3969/j.issn.1009-6469.2023.09.040 |
| 中文关键词: 肺炎，病毒性 吸入用乙酰半胱氨酸溶液 重组人干扰素 α2b 儿童，学龄前 |
| 英文关键词: Pneumonia, viral Inhaled acetylcysteine solution Recombinant human interferon α2b Child, preschool |
| 基金项目:合肥市卫生健康委 2021年度应用医学研究项目( Hwk2021zd016) |
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| 中文摘要: |
| 目的观察吸入用乙酰半胱氨酸溶液联合雾化吸入重组人干扰素 α2b(rhIFNα2b)治疗小儿病毒性肺炎的临床疗效。方法选取安徽省妇幼保健院 2019年 9月至 2021年 3月收治住院的病毒性肺炎病儿 100例，依据随机数字表法，把病例分为对照组和观察组，每组 50例。对照组病儿给予常规治疗同时雾化吸入 rhIFNα2b注射液，每次 200 000 IU/kg，每天 2次；观察组在对照组基础上予吸入用乙酰半胱氨酸溶液每次 3 mL雾化吸入治疗，每天 2次。通过观察两组病例病毒性肺炎的转归，比较两组病例咳嗽缓解天数、肺部啰音消失的天数、住院天数，及两组治疗的总有效率和不良反应发生率。结果观察组病例咳嗽缓解天数、肺部啰音消失天数、住院天数均低于对照组( P<0.05)；观察组病例治疗总有效率 94.0%(47/50)对照组病例治疗总有效率 80.0%(40/50)，两组差异有统计学意义( P<0.05)；两组不良反应发生率差异无统计学意义( P>0.05)。，结论吸入用乙 |
| 英文摘要: |
| Objective To observe the clinical efficacy of inhalation of acetylcysteine solution combined with atomized inhalation ofrecombinant human interferon α2b (rhIFNα2b) in the treatment of pediatric viral pneumonia.Methods A total of 100 children with vi- ral pneumonia admitted to Anhui Maternal and Child Health Hospital from September 2019 to March 2021 were selected, and the caseswere divided into a control group and an observation group based on the method of randomized numerical table, with 50 cases in eachgroup. Children in the control group were given routine treatment and nebulized inhalation of rhIFNα2b injection at 200 000 IU/kgtwice a day, while children in the observation group were given inhalation of acetylcysteine solution at 3 mL twice a day on the basis ofthe control group. By observing the regression of viral pneumonia in the two groups, we compared the number of days of cough relief,the number of days of disappearance of lung rales, the number of days of hospitalization, the total effective rate and the incidence rate ofadverse reactions in the two groups.Results The cough relief days, lung rales disappearance days and hospital days in the observationgroup were lower than those in the control group, and the difference was statistically significant (P < 0.05). The total effective rate of thetreatment of cases in the observation group was 94.0% (47/50), and the total effective rate of the treatment of cases in the control groupwas 80.0% (40/50); the difference was statistically significant (P < 0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant (P > 0.05).Conclusion The efficacy of inhaled acetylcysteine solution combined withrhIFNα2b atomization inhalation for the treatment of pediatric viral pneumonia is significant, with no significant increase in the inci-dence of adverse reactions, and is worthy of clinical promotion and application. |
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